Volume 16, Issue 4

Original Article(continued)

1. Multi-Target Inhibition of Breast Cancer Receptors by Pomegranate Peel Phytochemicals: An Integrated Docking, MD Simulation, and DFT Study

   Magesh Mohan, Renukadevi Jeyavelkumaran, Sanjay Valliappan, Shakthi Harikrishnan, Kadir Aravindan, Balaji Ravikuma

   pp. 1601-1621 · DOI: 10.5530/ijpi.20260291 · 2026

   Background: Breast cancer progression is governed by highly interconnected signaling networks involving receptor tyrosine kinases and hormone-responsive nuclear receptors, which collectively drive tumor heterogeneity, ad…

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2. Comparative Analysis of Three COVID-19 Vaccines in Indian Metros

   Md. Zeyaullah, Kamal Ahmad

   pp. 1622-1628 · DOI: 10.5530/ijpi.20260014 · 2026

   Background: This study evaluates COVID-19 vaccination coverage, vaccine effectiveness against SARS-CoV-2 variants, and associated health consequences in the five most important Indian metropolitan cities: Delhi, Mumbai, …

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3. Development and Optimization of a Validated UV Spectrophotometric for Simultaneous Estimation of Thymoquinone and Temozolomide

   Krutika Lolsure, Vijay Kumbar, Priya Shetti, Mitali Kubade, Malleswara Peram

   pp. 1629-1634 · DOI: 10.5530/ijpi.20260016 · 2026

   Introduction: Glioblastoma multiforme, an extremely aggressive form of brain cancer, presents significant challenges in treatment, despite the application of surgical intervention, radiation therapy, and chemotherapy. Re…

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4. Mechanistic Investigation of Hidden Flavonoids Isoorientin and Hyperin as Pancreatic Lipase Inhibitors Using Molecular Simulations and Machine Learning Correlation

   Sruthi Sai Kaveripakam, Sreedevi Adikay, Sowmya Venkata Donthamsetty, Surekha Lakshmi Khandavilli

   pp. 1635-1641 · DOI: 10.5530/ijpi.20260025 · 2026

   Background: Phytochemicals exhibit diverse therapeutic properties with minimal adverse effects and documented their benefits against metabolic disorders. Inhibition of pancreatic lipase is a validated strategy for managi…

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5. Structure-Guided Virtual Screening and Molecular Dynamics Simulation of Selective Small-Molecule Inhibitors Targeting E3 Ubiquitin Ligase MDM2 in Breast Cancer

   Tahani Bakhsh

   pp. 1642-1656 · DOI: 10.5530/ijpi.20260058 · 2026

   Background: MDM2 is an E3 ubiquitin ligase that suppresses p53, promotes its degradation, inhibits apoptosis, and drives uncontrolled cancer cell growth. Targeting the MDM2-p53 interaction is therefore a promising strate…

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6. Thematic Structure and Evolution of a Pharmaceutical Sciences Research Corpus from Dr. Anroop Nair

   K. K Mueen Ahmed, M Chaman Sab, Mohammed Yunus, Shery Jacob, Jigar N. Shah, Hiral J. Shah, Mahesh Attimarad, Sreeharsha Nagaraja, Rashed M. Almuqbil, Bandar E. Al-Dhubiab, Katharigatta N. Venugopala, Abdullah M. Alotaibi, Ahmed S. Alnaim

   pp. 1657-1665 · DOI: 10.5530/ijpi.20260004 · 2026

   Objective: Drug delivery and pharmaceutical-analysis research spans a wide range of sub-disciplines - nanocarrier formulation, transdermal and iontophoretic delivery, analytical method development, and computational drug…

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7. Development of a Paediatric-Friendly Pullulan-Based Mouth Dissolving Film of Ferrous Bisglycinate Using Factorial Design and Electronic Tongue-Assisted Taste Evaluation

   Jahanvi Patel, Tejal Mehta

   pp. 1666-1679 · DOI: 10.5530/ijpi.20260292 · 2026

   Background: The primary objective of this study was to develop, optimize and evaluate a paediatric-friendly, pullulan-based Mouth Dissolving Film (MDF) of Ferrous Bisglycinate as a novel iron delivery system. The work ai…

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8. GC-MS and UV-visible Spectroscopic Analysis of Bioactive Phytochemical in Trigonella foenum-graecum Visible Spectroscopic

   S. Revathy, K. Shoba, A. Vidhya

   pp. 1680-1695 · DOI: 10.5530/ijpi.20260024 · 2026

   Background: Trigonella foenum-graecum (fenugreek) is a widely utilized medicinal herb known for its therapeutic potential in managing metabolic disorders. This study aimed to extract and characterise the bioactive consti…

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9. Computational Simulation of Monoamine Oxidase (PDB ID: 2BXR) “Molecular Docking, Molecular Dynamics, and 3D-QSAR Analysis of 10H-Phenothiazin-1-yl Derivatives Targeting Enzymes”

   Sanket Keshav Tambe, Rohit Jaysing Bhor, Sagar Dattatray Magar, Mayur Shivaji Bhosale, Shubham Popatrao Mankar, Datta Macchindra Abhale, Sachin Tukaram chavan, Gaurav Subhash Damre

   pp. 1696-1718 · DOI: 10.5530/ijpi.20260011 · 2026

   Background: This study focuses on the computational (in silico) analysis of 1H-phenothiazine derivatives to estimate their pharmacological potential, particularly as inhibitors of monoamine oxidase (PDB ID: 2BXR), an enz…

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10. Assessment of Health-Related Quality of Life after the Second Cycle of Chemotherapy in Esophageal Cancer Patients: A Prospective Cross-Sectional Study

    Vishal Kulkarni, Kavya Mattikatti, Manasa Desai, Darshan Randewadi, Nida Sirdesai, Sanatkumar Bharamu Nyamagoud, AHM Viswanatha Swamy

    pp. 1719-1724 · DOI: 10.5530/ijpi.20260176 · 2026

    Aim: To evaluate early changes in symptom-specific Health-Related Quality of Life (HRQoL) among Esophageal cancer patients receiving chemotherapy up to the second cycle and to assess demographic and treatment-related dif…

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