Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery
1★, 1, 2, 3, 3★ Corresponding author
- 1Department of Pharmaceutics, Atmiya Institute of Pharmacy, Kalawad Road.
- 2Smt. R. D. Gardi B. Pharmacy College, Nyara.
- 3Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, INDIA.
CORRESPONDENCE
Jaydeep Patel
Department of Pharmaceutics, Atmiya Institute of Pharmacy, Kalawad Road.
Received: 11-01-2011; Revised: 21-02-2011; Accepted: 02-02-2011.
Volume 1, Issue 2 · pp. 112-118 · 2011 · DOI: 10.4103/2230-973X.82431
ABSTRACT
Background and Aim: Telmisartan (TEL) is an angiotensin II receptor blocker (ARB) antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water soluble TEL.Materials and Methods: The solubility of TEL in various oils was determined to identify the oil phase of a SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. A SNEDDS was further evaluated for its percentage transmittance, emulsification time, drug content, phase separation, dilution, droplet size, zeta potential, pH, refractive index, and viscosity.Results: The developed SNEDDS formulation contained TEL (20mg), Tween® 20 (43.33%w/w), Carbitol® (21.67%w/w), and Acrysol® EL 135 (32%w/w). The optimized formulation of the TEL-loaded SNEDDS exhibited a complete in vitro drug release in 15min as compared with the plain drug, which had a limited dissolution rate. It was also compared with the pure drug suspension by oral administration in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of TEL from the SNEDDS compared with the pure drug suspension.Conclusions: These results suggest the potential use of the SNEDDS to improve the dissolution and oral bioavailability of poorly water soluble TEL.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Patel, J., Kevin, G., Patel, A., Raval, M., & Sheth, N. (2011). Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. International Journal of Pharmaceutical Investigation, 1(2), 112-118. https://doi.org/10.4103/2230-973X.82431
Copyright and licence
© 2011 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0