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Electrospun Fibrous Mat of Cellulose Acetate: Influence of Solvent System (Acetic Acid/Acetone) on Fibers Morphology

1★★ Corresponding author

  1. 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, LEBANON.

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Mohammed Maher Mehanna

Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, LEBANON.

mmhanna@bau.edu.lb

Volume 10, Issue 1 · pp. 82-85 · 2020 · DOI: 10.5530/ijpi.2020.1.15

ABSTRACT

Objectives: Electrospun Cellulose Acetate (CA) fibers system are of high demand due to its desired properties associated with the final fiber features. This polymer inability to dissolve may hinder its electrospinning processing. The goal of the current study is to explore the fiber forming ability of solvent mixture of varying ratios of acetone and acetic acid and to derive the optimized formulation that facilitate the continuous and uniform CA fiber formation.Methods: In this study, a new solvent system for electrospinning of cellulose acetate is developed for the preparation of continuous uniform CA fibers. Different concentrations of cellulose acetate are dissolved in solvent system consisting of acetic acid/acetone mixture. The polymer solution prepared was hosted in a mechanical syringe pump, with a stainless-steel blunt end needle fixated to the tip acting as the spraying nozzle. The polymeric cellulose acetate in acetone/acetic acid mixture was examined for its viscosity and electrical conductance. Moreover, the formed cellulose acetate-based fibers were morphologically examined.Results: The solvent system composition as well as the cellulose acetate concentration affected the final CA fiber morphology, where the 10% cellulose acetate solution in acetone: acetic acid at 9:1 ratio presented uniform fiber morphology with a diameter of 549±45 nm. The solvent system optimized preserved continuous and uniform, beads-free CA fibers.Conclusion: In the current study, the different solvent systems studied presented different fiber morphologies and diameter sizes thus preserving the importance of the solvent system for the cellulose acetate fine fiber production.

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    Mehanna, M. M. (2020). Electrospun Fibrous Mat of Cellulose Acetate: Influence of Solvent System (Acetic Acid/Acetone) on Fibers Morphology. International Journal of Pharmaceutical Investigation, 10(1), 82-85. https://doi.org/10.5530/ijpi.2020.1.15

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    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0