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Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations

1, 1, 1

  1. 1Department of Chemistry, Jai Narain Vyas University, Jodhpur, Rajasthan, INDIA.

CORRESPONDENCE

Seema Parveen

Assistant Professor, Department of Chemistry, Jai Narain Vyas University, Jodhpur. Jodhpur-342001, Rajasthan, INDIA.

seemakhan2831@gmail.com

Received: 24-05-2022; Revised: 18-06-2022; Accepted: 12-08-2022.

Volume 12, Issue 4 · pp. 455-461 · 2022 · DOI: 10.5530/ijpi.2022.4.78

ABSTRACT

Background: This research was focused on the development of a quick, simple, precise, and cost-effective voltammetric method for quantifying dosulepin.Materials and Methods: The antidepressant drug (dosulepin) was assessed in pharmaceutical formulations using square wave voltammetric (SWV) and Differential pulse voltammetric (DPV) techniques at a glassy carbon potentiometric working electrodes (GCE).Results: Dosulepin demonstrated a single clear and sharp cathodic peak in the applied potential -0.7 to -0.75 V versus Ag/AgCl/KCl reference electrode. Results from cyclic voltammetry, DPV, and SWV revealed one reduction wave with a peak potential of -0.7 V at pH 7. The proposed method’s excellent sensitivity was demonstrated by the obtained LOD of 7.686 x10- 8mol L-1and a LOQ of 2.589x10-7mol L-1bulk were by applying Differential Pulse Voltammmetry method. On other hand a LOD of 1.735x10-7mol L-1and a LOQ of 5.785x10-7mol L-1bulk dosulepin were achieved by applying the Square Wave Voltammetry method.Conclusion: The suggested methods might be recommended for usage in quantitative detection, product testing, and research laboratories.

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    Saini, R. L., Parveen, S., & Bais, R. (2022). Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations. International Journal of Pharmaceutical Investigation, 12(4), 455-461. https://doi.org/10.5530/ijpi.2022.4.78

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    © 2022 Author(s)

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