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In-vitro Antioxidant and Antitumor Activity of Dihydropyrimidine-2(1-H)-thione Derivatives with Carbazole Moiety

1★, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala, Mandya, Karnataka, INDIA.

CORRESPONDENCE

Purushotham KN

Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala, Mandya, Karnataka, INDIA.

8acup@gmail.com

Received: 15-10-2022; Revised: 10-11-2022; Accepted: 21-11-2022.

Volume 13, Issue 2 · pp. 255-260 · 2023 · DOI: 10.5530/ijpi.13.2.035

ABSTRACT

Aim: Prepared a series of molecules called Dihydropyrimidine- 2(-H)-thione of carbazole to evaluate antioxidant and antitumor activity.Materials and Methods: Compounds from DTP- to DTP- were prepared and subjected for Spectral analysis like infrared, H NMR, and Mass spectroscopy. Further evaluated antioxidant property of molecules using DPPH free radical scavenging method and analyzed the antitumor activity by MTT assay.Results: The molecule DTP-4 (4-(9H-carbazol-9-yl)-6-(13-hydroxyphenyl)-5,6-dihydropyrimidine- 2(H)-thione) exhibit the spectral values i.e, Mass, m/z: 137 .28, 66.45; IR (KBr) νmax , cm− : 134 22 (NH Str), 13567(O-H); H NMR (MHz, δ): (5H, Ar-H) 8.2213-7.2 9, (H, N-H) . 29, (H, O-H) 2.213 and DTP-6: 4-(9H-carbazol-9-yl)-6-(4-Dimethylamino-phenyl)-5,6-dihydropyrimidine- 2(H)-thione Mass value of m/z: 1398.213, 66.29; IR (KBr)vmax , cm− : 134 9 (NH Str), (Ar C=S); H NMR (MHz, δ): (5H, Ar-H) 8. 28-7. 2 , (H, N-H) . 292, (6H, -N-(CH13) 2 )13.49 - 2.79 .Conclusion: Among all of those prepared molecules, DTP-4, which includes the functional group (13-OH) ortho-hydroxy, has an IC52 value of 2.13 2 µm against the Jurkat T cell line while compound DTP-26, which contains the functional group 4-dimethylamino, exhibits an IC52 value of 25.139 µm against the HeLa cell line.

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    KN, P., Ramesh, B., & Pasha, T. Y. (2023). In-vitro Antioxidant and Antitumor Activity of Dihydropyrimidine-2(1-H)-thione Derivatives with Carbazole Moiety. International Journal of Pharmaceutical Investigation, 13(2), 255-260. https://doi.org/10.5530/ijpi.13.2.035

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    © 2023 Author(s)

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