International Journal of Pharmaceutical Investigation logo
Submit
International Journal of Pharmaceutical InvestigationACADEMIC PUBLISHING
Article

Effect of Yohimbine on STZ Induced Diabetic Rats

1, 2, 3★★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
  2. 2Center for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
  3. 3Department of Pharmacology, Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Thimmapur, Karimnagar, Telangana, INDIA.

CORRESPONDENCE

Anreddy Rama Narsimha Reddy

Department of Pharmacology, Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Thimmapur, Karimnagar, Telangana, INDIA.

petasudhakar@gmail.com

Received: 10-03-2023; Revised: 26-04-2023; Accepted: 11-05-2023.

Volume 13, Issue 3 · pp. 532-537 · 2023 · DOI: 10.5530/ijpi.13.3.066

ABSTRACT

Background: Yohimbine has been suggested as a possible therapy for type 2 diabetes mellitus. Thus, we evaluated antidiabetic activity of yohimbine in Streptozocin (STZ)-induced rats.Materials and Methods: Yohimbine's anti-diabetic effects were investigated by giving male Wistar rats an injection of Streptozotocin (STZ) to cause diabetes and then analyzing their blood samples. Blood Glucose Levels (BGLs) and glucose tolerance was recorded using an FBG and an OGTT, respectively. Triglyceride, Low-Density Lipoprotein (LDL-c), and High-Density Lipoprotein (HDL-c) levels were determined to examine the impact of yohimbine administration on the lipid profile of diabetic rats. Finally, yohimbine's impact on pancreatic histological damage due to diabetes was investigated.Results: Overall, our findings imply that yohimbine, an alpha-2 adrenoceptor antagonist, helped diabetic group have better glucose tolerance. Yohimbine-treated mice had lower BGLs and enhanced lipid profiles, with lessened triglyceride and LDL-c levels and improved HDL-c levels. Histopathological analyses showed that the size and density of pancreatic cells had increased and that they had regenerated remarkably.Conclusion: As a result, we can conclude that yohimbine may have therapeutic value for restoring lipid-carbohydrate equilibrium and in repairing diabetes-related pancreatic damage.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sudhakar, P., Satla, S. R., & Reddy, A. R. N. (2023). Effect of Yohimbine on STZ Induced Diabetic Rats. International Journal of Pharmaceutical Investigation, 13(3), 532-537. https://doi.org/10.5530/ijpi.13.3.066

    Copyright and licence

    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0