International Journal of Pharmaceutical Investigation logo
Submit
International Journal of Pharmaceutical InvestigationACADEMIC PUBLISHING
Article

Formulation and Evaluation of Propranolol Hydrochloride Sustained Release Matrix Tablets Using Different Grades of HPMC and MCC

1, 1, 1, 1, 1, 1★, 1★ Corresponding author

  1. 1Department of Pharmaceutical Technology, Brainware University, Ramkrishnapur Road, Barasat, Kolkata, West Bengal, INDIA.

CORRESPONDENCE

Prasenjit Mondal

Department of Pharmaceutical Technology, Brainware University, Ramkrishnapur Road, Barasat, Kolkata, West Bengal, INDIA.

prasenjitmyname@gmail.com

Received: 15-06-2023; Revised: 01-07-2023; Accepted: 30-07-2023.

Volume 13, Issue 4 · pp. 763-771 · 2023 · DOI: 10.5530/ijpi.13.4.094

ABSTRACT

Background: To design and develop propranolol hydrochloride sustained-release tablet formulations using different grades of HPMC and MCC and their in vitro evaluations. The effect on drug release from tablets and other characteristics by various grades of polymers were studied and compared.Materials and Methods: Propranolol hydrochloride, microcrystalline cellulose (PH-101), Microcrystalline Cellulose (PH-102), HPMC (K15 M), HPMC (K100 M), HPMC (K4 M), HPC LF, Isopropyl alcohol, Povidone (K-30), Magnesium Stearate were used in the different formulations. Direct compression, dry granulation and wet granulation methods were used for the preparation of tablets.Results: Among different formulations, SR008 having HPMC K100M was showing better sustained release characteristics, 69.1%, 76.6%, 82.3% for 8, 10, 12 hr respectively compared to other formulations with 71% moisture content and 71N hardness.Conclusion: The matrix embedding technique using HPMC K100M has successfully extended the release of propranolol hydrochloride. It is particularly suitable for obtaining directly compressed sustained-release matrix tablets with appropriate standards and well-reproducible drug release profiles. In contrast to thrice daily prescriptions of the conventional formulation, the designed formulations can be prescribed once daily dose leading to a reduction in dosing frequency and per-day drug dose. It is concluded that HPMC K100M in appropriate proportions is suitable for formulating sustained-release tablets which exhibit diffusion-controlled Higuchi kinetics for propranolol hydrochloride.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Khamkat, P., Barik, V., Barik, B. B., Chakraborty, A., Patra, D., Mondal, P., & Chatterjee, S. (2023). Formulation and Evaluation of Propranolol Hydrochloride Sustained Release Matrix Tablets Using Different Grades of HPMC and MCC. International Journal of Pharmaceutical Investigation, 13(4), 763-771. https://doi.org/10.5530/ijpi.13.4.094

    Copyright and licence

    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0