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Zinc cross-linked hydroxamated alginates for pulsed drug release

1, 1, 1, 1★★ Corresponding author

  1. 1Departments of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, INDIA.

CORRESPONDENCE

Nandkishor R Kotagale

Departments of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, INDIA.

nandukotagale@gmail.com

Volume 3, Issue 4 · pp. 194-202 · 2013 · DOI: 10.4103/2230-973X.121292

ABSTRACT

Introduction: Alginates can be tailored chemically to improve solubility, physicochemical, and biological properties and its complexation with metal ion is useful for controlling the drug release.Materials And Methods: Synthesized N,O- dimethyl, N-methyl, or N-Benzyl hydroxylamine derivatives of sodium alginate were subsequently complexed with zinc to form beads. Hydroxamation of sodium alginate was confirmed by Fourier transform infra-red spectroscopy (FTIR) and differential scanning calorimetry (DSC).Results: The synthesized polymeric material exhibited reduced aqueous, HCl and NaOH solubility. The hydroxamated derivatives demonstrated pulsed release where change in pH of the dissolution medium stimulated the atenolol release.Conclusion: Atenolol loaded Zn cross-linked polymeric beads demonstrated the sustained the plasma drug levels with increased half-life. Although the synthesized derivatives greatly altered the aqueous solubility of sodium alginate, no significant differences in in vitro and in vivo atenolol release behavior amongst the N,O-dimethyl, N-methyl, or N-Benzyl hydroxylamine derivatives of sodium alginate were observed.

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    Raut, N. S., Deshmukh, P. R., Umekar, M. J., & Kotagale, N. R. (2013). Zinc cross-linked hydroxamated alginates for pulsed drug release. International Journal of Pharmaceutical Investigation, 3(4), 194-202. https://doi.org/10.4103/2230-973X.121292

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    © 2013 Author(s)

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