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Evaluation of efficacy and safety of Ayucid capsule in subjects suffering from chronic symptomatic gastroesophageal reflux disease

1★, 2, 3, 4, 3, 4, 1★ Corresponding author

  1. 1Department of Medical Research, Target Institute of Medical Education and Research, Mumbai.
  2. 2Department of Rasashastra and Bhaishajya Kalpana, Ayurveda Research Centre, Ayurved Seva Sangh, Nashik.
  3. 3Department of Kayachikitsa, PDEA’s College of Ayurveda and Research Centre, Pune.
  4. 4Department of Kayachikitsa, KVTR Ayurvedic College, Boradi, Maharashtra, INDIA.

CORRESPONDENCE

Sanjay M. Tamoli

Department of Medical Research, Target Institute of Medical Education and Research, Mumbai.

sanjaytamoli@hotmail.com

Volume 8, Issue 2 · pp. 100-105 · 2018 · DOI: 10.4103/jphi.JPHI_35_18

ABSTRACT

Objectives: The objective of the study was to assess the efficacy and safety of Ayucid capsule and Omeprazole 20 mg in patients suffering from chronic symptomatic gastroesophageal reflux disease (GERD).Materials and Methods: It was an open‑label, randomized, comparative, multicenter, prospective clinical study. Subjects in Ayucid group were advised to consume two Ayucid capsules twice daily orally before meals, and subjects in Omeprazole group were advised to consume one Omeprazole (20 mg) capsule orally before lunch for 28 days. All P values were reported based on two‑sided significance test, and all the statistical tests were interpreted at 5% level of significance.Results: A total of 63 subjects (33 in Ayucid group and 30 in Omeprazole group) completed the study. At the end of the study, the number of cases of heartburn and symptom of heartburn and severity scores of acid regurgitation, dysphasia, and nausea reduced significantly (P 0.05) changes were observed in safety laboratory parameters and vitals. Of the reported adverse events in the two groups, none were found to be related to the study drugs.Conclusion: Ayucid capsule is equally effective or noninferior to that of Omeprazole capsule in relieving the GERD symptoms.

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    Tamoli, S. M., Pande, S. P., Deshpande, S. V., Mundhe, N. B., Doiphode, M. V., Kolhe, G. S., & Upasani, S. A. (2018). Evaluation of efficacy and safety of Ayucid capsule in subjects suffering from chronic symptomatic gastroesophageal reflux disease. International Journal of Pharmaceutical Investigation, 8(2), 100-105. https://doi.org/10.4103/jphi.JPHI_35_18

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    © 2018 Author(s)

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