Volume 16, Issue 2

Original Article

1. Formulation, Optimization, and Evaluation of Lornoxicam Medicated Chewing Gum Using Ion Exchange Resin Taste Masking

   Kinjal Shah, Hemani Joshi, Shailvi Shah, Tejal Mehta

   pp. 569-578 · DOI: 10.5530/ijpi.20260096 · 2026

   Background: This study aimed to develop and evaluate a taste-masked Medicated Chewing Gum (MCG) of Lornoxicam (LXM) using Kyron T-114, a weak cation exchange resin, to improve palatability and patient compliance. LXM, a …

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2. Modulating Metabolic and Cardiovascular Adverse Effects of Olanzapine with Theobroma cocoa a Preclinical Insight into Synergistic Cardioprotection

   Varsha Aniket Patole, Santosh Bhausaheb Dighe, Sapna Baban Khemnar, Gaurao subhash damare, Vaibhav vitthal bhone, Shweta Shantaram Jadhav

   pp. 579-584 · DOI: 10.5530/ijpi.20260113 · 2026

   Background: Olanzapine, a widely prescribed atypical antipsychotic, is associated with significant cardiometabolic side effects, including hypertension, dyslipidaemia, oxidative stress, inflammation, and QT interval prol…

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3. Screening of Phytochemicals as PIP5K1α Protein Inhibitors for Breast Cancer Treatment: A Bio Computational Study

   Ahmed Mulfi Alharbi

   pp. 585-589 · DOI: 10.5530/ijpi.20260049 · 2026

   Aim/Background: Breast Cancer (BC) is one of the most common cancers affecting women globally. PIP5K1α catalyzes PtdIns-4,5-P2 (PIP2), a Precursor to PtdIns-3,4,5-P3 (PIP3), required for AKT activation. Overexpression of…

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4. Drug Utilization Evaluation of Proton Pump Inhibitors in the General Medicine Ward of a Tertiary Care Hospital

   Shivalingayya Gadagayya Hiremath, Umesh Chaudhary, Giridhar Koratagere Sreekanth, Sai Keerthana Ravishankar, Manikanta Devaraj, Shailesh Yadav

   pp. 590-598 · DOI: 10.5530/ijpi.20260331 · 2026

   Background: Proton Pump Inhibitors (PPIs) are the most effective agents for managing acid related disorders. However, Inappropriate Prescribing of PPIs is becoming an issue of concern. Purpose: To review proton pump inhi…

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5. Drug Utilization Evaluation of Antibiotics in an Indian Hospital Setting: A Prospective Observational Study

   Sanatkumar Bharamu Nyamagoud, Laxmi Bhimappa Totar, Hema Yadav, S M Shoaib Ahamed, Khandke Shruti Achyut, Vaishanavi Vanasakrithmath, R Ranjani, Tanushree R Bantanur, Chandan Ashok Naik, Shivani Mathapati, Spoorthi G Lakkannavar, K H Karthik

   pp. 599-605 · DOI: 10.5530/ijpi.20260421 · 2026

   Background: Rational drug use is essential to improving healthcare outcomes and minimizing risks such as antimicrobial resistance. This study evaluates prescription patterns in the General Medicine Department of an India…

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6. Preparative Separation, Identification and Characterization of N-Acylated Impurity in Ciprofloxacin Eye Drops Formulations Using 1D and 2D NMR Techniques

   Bhupinder Kumar, Raju Mudhulkar, Sreedhar Gundekari, Surbhi Tiwari, Dama Venugopala Rao, Lakki Reddy Prakash, Ramakrishna Yadav Belly, Sandeep Kumar

   pp. 606-617 · DOI: 10.5530/ijpi.20260460 · 2026

   Background: Packaging, storage and transportation of under varying climatic conditions have the quality concern in the drug products. This study followed the observed unknown impurity of ciprofloxacin eye drop. Materials…

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7. In silico Analysis of 6, 6’-Dihydroxythiobinupharidine on the Enzymes Involved in Cognitive Impairment

   Pranav Nayak, Mohammad Ali, DR Bharathi

   pp. 618-624 · DOI: 10.5530/ijpi.20260468 · 2026

   Background: Cognitive impairment signifies a reduction in mental abilities resulting from different factors like Alzheimer's disease leading to a diminished quality of life. Detecting it early and implementing interventi…

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8. DAVID and KEGG-Based Functional Enrichment Analysis of Breast Cancer Transcriptome: Mapping ECM Remodeling and Cell Division Pathways

   Akram Ahmed Aloqbi

   pp. 625-637 · DOI: 10.5530/ijpi.20260075 · 2026

   Background: Breast cancer, affecting roughly 2.3 million people each year, stands as a major global health concern due to its molecular complexity across subtypes such as luminal, HER2-enriched, and triple-negative. Thes…

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9. Neuroprotection and Oxidative Stress Reduction by Bacillus coagulans: An in vitro Comparison with Escitalopram

   Usha Dhoddametikurke Siddappa, Mandara Mathighatta Suresh, Mohd Sharique Katchhi, Babiker Bashir Haroun Baraka, Shilpashree Bettadapura Muralidhar, Chinthana Handankere Basavaraju, Chakure Aditya, Jyothi Murthy, Rajamma Abburu Jayaramu

   pp. 638-644 · DOI: 10.5530/ijpi.20260558 · 2026

   Background: Neurodegenerative and psychiatric disorders are often linked to oxidative stress and mitochondrial dysfunction, necessitating novel therapeutic strategies. Bacillus coagulans, a probiotic known for its role i…

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10. Detection of Various Poison in Biological Sample Using High Performance Thin Layer Chromatography

    Jayasutha Jayram, Jerad Suresh Ayyadurai, Jagadeesan Subramanian, Lokesh kumar Dhavanam Ramesh Babu, Mohanraj vadivelu, Naveen Raj Ravi Kumar, Silviya Jenifer John Bosco, Pravin Kumar Muthukumaresan, Sathya Samikkannu, Yashwan Babu, Raman Lakshmisundaram, Ramakrishnan Trichur Venkatakrishnan

    pp. 645-653 · DOI: 10.5530/ijpi.20260608 · 2026

    Background: Poisoning is a major public health issue in many countries, particularly in India, where exposures to pesticides, household agents, drugs, industrial chemicals, and animal toxins are common. Contributing fact…

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11. Computational Tool and Molecular Properties to Identify the Molecular Targets of Novel Benzimidazole Derivatives as Potential COX Inhibitors via in silico Approaches

    Vinod Rajendra Tawate, Sanket Keshav Tambe, Shubham Popatrao Mankar, Nilima Mahesh Wani, Sneha Abhishek Vikhe, Manisha Dhondiram Sonawane, Rohit Jaysing Bhor

    pp. 654-666 · DOI: 10.5530/ijpi.20260528 · 2026

    Background: Using a variety of computational techniques, in silico studies allow for forecasting structural changes and how they would impact the pharmacological properties as well as the efficiency of these modification…

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12. Evaluating the Safety and Efficacy of Hydroxyurea in Adult Sickle Cell Disease: A Prospective Observational Study

    Rajesh Hadia, Kular Simran, Param Bhatt, Priyanka Yadav, Sarvajeet Khare, Cyril Sajan, Varunsingh Saggu, Hemraj Singh Rajput, Jitendra Lakhani

    pp. 667-678 · DOI: 10.5530/ijpi.20260007 · 2026

    Background: Sickle Cell Disease (SCD) is characterized by recurrent hospitalizations and painful Vaso-Occlusive Crises (VOCs). VOCs are prevalent and often necessitate hospital admissions. Aim and Objectives: This study …

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13. Formulation and Evaluation of Antiacne Emulgel Using Aloe vera

    Kamaladevi Kshatriya, Shivanand Swamy Panchayya Hiremath, Jathin Subhash Kalal, Fatima Sanjeri Dasankoppa, M Mahesh Yadav, Pradeep Bhimagouda Mirje, Jayatheertha Lokapur, Arpitha Lokapur, Rohan Ravsaheb Latwade, Pranav Babasaheb Patil

    pp. 679-686 · DOI: 10.5530/ijpi.20260041 · 2026

    Introduction: Emulgels are emerging as efficient topical drug delivery systems due to their dual-release mechanism, combining the benefits of both emulsions and gels. This system facilitates the enhanced delivery of hydr…

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14. Phyllanthin Topical Formulation with Penetration Enhancers Alleviates Imiquimod-Induced Psoriasis in Rats via Modulation of Inflammatory Biomarkers and Oxidative Stress Markers

    Papiya Bigoniya, Vanita Chature

    pp. 687-701 · DOI: 10.5530/ijpi.20260554 · 2026

    Background: Psoriasis is a persistent inflammatory skin condition marked by abnormal epidermal proliferation and excessive keratinization, impairing effective drug absorption. To overcome these barriers, topical formulat…

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15. In vitro Antioxidant and Antiglycemic Effects of Malus domestica, Musa acuminata Colla, Mangifera indica, Citrus reticulata and Punica granatum Fruits Peel Extracts

    C Reddy Prasad, Bibi Umeza, M Yuvaraj, A K Afzal Khan, Swapna R Nayaka, Thirunavukkarasu Jayaraman

    pp. 702-707 · DOI: 10.5530/ijpi.20260059 · 2026

    Objectives: This study aims to evaluate the anti-glycemic and antioxidant qualities of Malus domestica fruit (apple), Musa acuminata Colla fruit (banana), Mangifera indica fruit (mango), Citrus reticulata fruit (orange),…

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16. Cardiovascular Disease Risk Factors in Diabetics with and without Metabolic Syndrome in NAFLD Patients

    Mohammad Shane Alam, Yahia Mjery, Kamal Ahmad, Yahia Ali Kaabi, Mohammad Suhail Akhter, Fakhra Jabeen, Jobran Mohammad Moshi, Alaa Ali Alhazmi, Md Intekhabul Haque, Saif Elden Babikar Abdalla, Mathkour Hazem

    pp. 708-714 · DOI: 10.5530/ijpi.20260150 · 2026

    Background: Globally, Non-Alcoholic Fatty Liver Diseases (NAFLD) is considered as the frequent chronic liver diseases strongly linked with metabolic dysfunction and cardiovascular risk specifically in Type 2 Diabetes Mel…

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17. Investigating the Prevalence of Pathogens and Drug Sensitivity in Catheter-Associated Urinary Tract Infections among ICU Patients: Insights from a Hospital-Based Cross-Sectional Study

    Navpreet Singh Babbar, Rabinoor Singh, Arti Saini, Inderjeet Verma, Tarun Singh

    pp. 715-721 · DOI: 10.5530/ijpi.20260403 · 2026

    Background: Catheter-Associated Urinary Tract Infections (CAUTIs) pose a major concern in Intensive Care Units (ICUs) due to their association with prolonged catheterization and severe underlying conditions. These infect…

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18. Comparison of Dermatology Life Quality Index and Skindex-16 Questionnaires in Breast Cancer Patients with Radiation Dermatitis

    Rohith Kuppusamy, Keerthika Devaraj, Gayathri Thiruvengadam, Nandhakumar Kannan, Mohamed Ashik Ahamed Ibrahim, Sriniga Venkatesh, Raman Lakshmisundaram, Sindhu Selvam, Ruthresh Jaisankar, Aswin Venkadesh Ramamoorthy Renuga, Jayasutha Jayram, Satish Srinivas Kondaveeti

    pp. 722-727 · DOI: 10.5530/ijpi.20260607 · 2026

    Background: Radiation Dermatitis (RD) is the most common adverse effect of radiation therapy among the cancer patients, which has the potential to lower patients' quality of life. This study aimed to assess the health-re…

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19. Formulation and Development of Euphorbia hirta Phytosomes Capsule for Treatment of Urinary Tract Infection

    Supriya Waghmare, Shreeya Belwalkar, Amir Shaikh, Sidhhi Bansode, Akancha Kumari, Pooja Deshmane, Archana Nagare, Mohini Bhawane, Nitin Salunkhe

    pp. 728-736 · DOI: 10.5530/ijpi.20260344 · 2026

    Background: Euphorbia hirta, also known as the "asthma plant" or "snake weed," belongs to the Euphorbiaceae family. However, its oral use as a drug has certain limitations, such as low bioavailability and high first-pass…

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20. Prevalence of Concomitant Use of Angiotensin Converting Enzymes Inhibitors and Angiotensin Receptors Blockers: A Retrospective Study

    Alhanouf Alhawiti, Mohamed TS Saleem, Ahmed Hasan Abdelazeem, Tahani Al Rahbeni

    pp. 737-743 · DOI: 10.5530/ijpi.20260138 · 2026

    Background: A retrospective study was conducted using Electronic Health Records (EHRs) from several hospitals in Saudi Arabia. Materials and Methods: All hypertensive patients who visited the hospitals between 2016 and 2…

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