Volume 6, Issue 4

Original Research Article

1. Bioadhesive floating microsponges of cinnarizine as novel gastroretentive delivery: Capmul GMO bioadhesive coating versus acconon MC 8‑2 EP/NF with intrinsic bioadhesive property

   Smita Raghuvanshi, Kamla Pathak

   pp. 181-193 · DOI: 10.4103/2230-973X.195923 · 2016

   Introduction: The study was aimed at the development of low-density gastroretentive bioadhesive microsponges of cinnarizine by two-pronged approach (i) coating with bioadhesive material and (ii) exploration of acconon MC…

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2. Mechanistic insights into acyclovir‑polyethylene glycol 20000 binary dispersions

   Krishnamoorthy Venkateskumar, Subramani Parasuraman, Raju Gunasunderi, Krishnan Sureshkumar, M. Muralidhar Nayak, Syed Adnan Ali Shah, Khoo Kassen, Heng Wei Kai

   pp. 194-200 · DOI: 10.4103/2230-973X.195925 · 2016

   Objective: The objective of this study is to provide a mechanistic insight into solubility enhancement and dissolution of acyclovir (ACY) by polyethylene glycol20000 (PEG20000). Materials and Methods: Solid dispersions w…

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3. Formulation development and evaluation of zolmitriptan oral soluble films using 22 factorial designs

   Poluri Koteswari, G. Puja Sravanthi, M. Mounika, S. K. Mohammed Rafi, K. Nirosha

   pp. 201-206 · DOI: 10.4103/2230-973X.195927 · 2016

   Objective: The present investigation involves the development of zolmitriptan oral soluble film (OSF) formulations and optimization with quality by design (QBD) using natural polymers and evaluation. Materials and Method…

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4. Formulation and development of plasma volume expander using natural and modified starch from Solanum tuberosum

   Nilima A. Thombre, Ajit V. Vishwakarma, Trupti S. Jadhav, Sanjay J. Kshirsagar

   pp. 207-217 · DOI: 10.4103/2230-973X.195930 · 2016

   Background: To formulation and development of plasma volume expander (PVE) by using natural and modified starch from Solanum tuberosum. The function of blood circulation is to provide the needs of the body tissues and to…

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5. Enhanced bioavailability of danazol nanosuspensions by wet milling and high‑pressure homogenization

   Naveen Kanthamneni, Satyanarayana Valiveti, Mita Patel, Heather Xia, Yin‑Chao Tseng

   pp. 218-224 · DOI: 10.4103/2230-973X.195931 · 2016

   Introduction: The majority of drugs obtained through synthesis and development show poor aqueous solubility and dissolution velocity, resulting in reduced bioavailability of drugs. Most of these problems arise from formu…

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6. Sodium dithionite‑enhanced quality of radix scutellariae through modification of secondary metabolism

   Guo Huimin, Fu Xiaoying, Du Hongwei, Cong Wei, Meng Xiangcai

   pp. 225-230 · DOI: 10.4103/2230-973X.195932 · 2016

   Introduction: The quality of radix scutellariae is particularly associated with environmental stresses, but detailed mechanisms remained unclear. Plant under unfavorable situation generates redundant reactive oxygen spec…

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7. Synergetic effects of silver and gold nanoparticles in the presence of radiofrequency radiation on human kidney cells

   Jafar Fattahi‑asl, Mojtaba Karbalaee, Masoud Sanatizadeh, Payam Amini

   pp. 231-237 · DOI: 10.4103/2230-973X.195933 · 2016

   Objective: The aim of this study was to compare the effects of radiofrequency radiation (RF) in synergism with gold (Au) and silver (Ag) nanoparticles (NPs) on the survival fraction of human normal kidney (HNK) and human…

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8. Development, evaluation, and influence of formulation and process variables on in vitro performance of oral elementary osmotic device of atenolol

   N. Arjun, D. Narendar, K. Sunitha, K. Harika, B. Nagaraj

   pp. 238-246 · DOI: 10.4103/2230-973X.195951 · 2016

   Purpose: Osmotic devices are the most promising strategy-based systems for controlled drug delivery. By optimizing formulation and processing parameters, possible to develop osmotic systems to deliver drugs at predetermi…

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