International Journal of Pharmaceutical Investigation logo
Submit
International Journal of Pharmaceutical InvestigationACADEMIC PUBLISHING
Article

Solubility of aceclofenac in polyamidoamine dendrimer solutions

1★, 1, 1, 2, 1★ Corresponding author

  1. 1Department of Pharmaceutics, Atmiya Institute of Pharmacy, Kalawad Road, INDIA.
  2. 2Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, INDIA.

CORRESPONDENCE

Jaydeep Patel

Department of Pharmaceutics, Atmiya Institute of Pharmacy, Kalawad Road, INDIA.

jmpatel7@gmail.com

Volume 1, Issue 3 · pp. 135-138 · 2011 · DOI: 10.4103/2230-973X.85962

ABSTRACT

In the present study we investigated the effect of polyamidoamine (PAMAM) dendrimers on the aqueous solubility of aceclofenac. The aqueous solubility of aceclofenac was measured in the presence of dendrimers in distilled water. The effect of variables, such as pH condition, concentration, temperature and generation (molecule size) of dendrimer, has been investigated. Results showed that the solubility of aceclofenac in the dendrimer solutions was proportional to dendrimer concentration. The order in which the dendrimers increased the solubility at a constant pH condition was G3 > G0. The influence of dendrimer solution pH on the solubility enhancement of aceclofenac suggests that it involves an electrostatic interaction between the carboxyl group of the aceclofenac molecule and the amine groups of the dendrimer molecule. The solubility of aceclofenac was inversely proportional to the temperature of dendrimer solution.Different generation (G0 and G3) PAMAM dendrimers have the potential to significantly enhance the solubility of poor water-soluble drugs.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Patel, J., Garala, K., Basu, B., Raval, M., & Dharamsi, A. (2011). Solubility of aceclofenac in polyamidoamine dendrimer solutions. International Journal of Pharmaceutical Investigation, 1(3), 135-138. https://doi.org/10.4103/2230-973X.85962

    Copyright and licence

    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0