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Dental Pulp Stem Cells: Biology and Promise for Regenerative Medicine

1★, 2★ Corresponding author

  1. 1Senior Registrar Pediatric Dentist, Department of Pedodontics, Prince Sultan Military Medical City, Riyadh, SAUDI ARABIA.
  2. 2Consultant Pediatric Dentist, Department of Pedodontics, Prince Sultan Military Medical City, Riyadh, SAUDI ARABIA.

CORRESPONDENCE

Alhanouf Binhezaim

Senior Registrar Pediatric Dentist, Department of Pedodontics, Prince Sultan Military Medical City, Riyadh, SAUDI ARABIA.

hanouf.k.hezaim@gmail.com

Received: 16-04-2023; Revised: 05-05-2023; Accepted: 01-06-2023.

Volume 13, Issue 3 · pp. 455-471 · 2023 · DOI: 10.5530/ijpi.13.3.057

ABSTRACT

Dental Pulp Stem Cells (DPSCs) offer great potential in regenerative medicine. Odontoblasts are naturally occurring cells that are responsible for constructing dentin for restorative dental purposes. Yet, their potential for use in the restoration of non-dental tissues is also being explored. Because of their similarities to BMSCs, DPSCs may be useful in musculoskeletal regenerative medicine, and they may be easily separated from teeth that have been pulled. Information on stem cells in dental pulp, transplantation, and immunomodulation was culled from the databases Scopus, PubMed, Web of Science, Science Direct, and Google Scholar. Differentiated Pluripotent Stem Cells (DPSCs) are not derived from bone marrow like BMSCs are. These phenotypic and genetic distinctions from BMSCs are being used in neurological and other settings. Pulp tissue regeneration and the therapeutic potential of DPSCs were discussed in this article. Prior to discussing their extensive uses in regenerative medicine, this article provides a brief background on the discovery and function of DPSCs.

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    Binhezaim, A., & Almutairi, T. (2023). Dental Pulp Stem Cells: Biology and Promise for Regenerative Medicine. International Journal of Pharmaceutical Investigation, 13(3), 455-471. https://doi.org/10.5530/ijpi.13.3.057

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    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0