International Journal of Pharmaceutical Investigation logo
Submit
International Journal of Pharmaceutical InvestigationACADEMIC PUBLISHING
Article

Synthesis and Anti-convulsant Activity of 1-[3-(4-Amin ophenyl)-3-Oxopropanoyl]- 5,5-Diphenyl imidazolidine -2,4-Dione and its Derivatives

1★, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.

CORRESPONDENCE

Rohit Jaysing Bhor

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.

rohit.bhor69@gmail.com

Received: 19-05-2023; Revised: 03-07-2023; Accepted: 28-07-2023.

Volume 13, Issue 4 · pp. 866-874 · 2023 · DOI: 10.5530/ijpi.13.4.109

ABSTRACT

Background: A heterocyclic hydrocarbon with distinct fundamental structural features in its molecular structure of 5, 5-diphenylimidazolidine heterocyclic ring. It is an imidazolidine and aromatic dibenzene fused ring. The flexible heterocyclic compounds that contain two atoms of nitrogen in 5, 5-diphenylimidazolidine. 5, 5-diphenylimidazolidine ring and its derivatives have a robust and promising biological action. In this study, we create a number of 1-[3-(4-ami nophenyl)-3-oxopropanoyl] derivatives. A compound with anticonvulsant properties is -5, 5-diphenylimidazolidine-2,4-dione (AC1). The Strychnine Induced Convulsion Method was used to test the pharmacological samples for anticonvulsant action. The compound 5,5-diphenylimidazolidine-2,4-dione was synthesized together with its 14 total derivatives.Materials and Methods: Benzoin; Benzil; Urea; Glacial Acetic Acid; 4-amino benzoic acid; Con. HNO3 ; Formic Acid; 2-Nitro Aniline; 4-Nitro Aniline; Aniline; Acetyl Chloride; Formic Acid; 4- amino Phenol are used for the synthesis. IR, NMR and MS are used for interpretation.Results: Our research led us to the conclusion that a variety of compounds have strong anti-convulsant properties. The compound 5,5-diphenylimidazolidine-2,4-dione (AB); 1-acetyl-5,5-diphenylimidazolidine-2,4-dione (AC); 1-[3-(4-hydroxy-2-[2-oxo-4 (phenylamino) ethyl]butanedioicacid)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (AC5); 1- [3-(4-oxo-4-(oxo(4-phenylamino)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (AC6); 1-[3-(4-(phenyl amino)benzoic acid) -3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (AC7) gives strong anti-convulsant effects against phenytoin drug.Conclusion: The title compounds and its derivatives were examined for their ability to treat convulsion. Studies of the relationship between structure and activity revealed that compounds containing 5, 5-diphenylimidazolidine derivatives that have an electron-withdrawing group have higher activity than those that have an electron-donating group.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Bhor, R. J., Rathod, P. M., & Nikam, P. (2023). Synthesis and Anti-convulsant Activity of 1-[3-(4-Amin ophenyl)-3-Oxopropanoyl]- 5,5-Diphenyl imidazolidine -2,4-Dione and its Derivatives. International Journal of Pharmaceutical Investigation, 13(4), 866-874. https://doi.org/10.5530/ijpi.13.4.109

    Copyright and licence

    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0