International Journal of Pharmaceutical Investigation logo
Submit
International Journal of Pharmaceutical InvestigationACADEMIC PUBLISHING
Article

A Box Behnken Design Optimized Nano Vesicular Transdermal Patch for Allergies

1★, 2★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, JNTUA, Ananthapuramu, Andhra Pradesh, INDIA.
  2. 2Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Affiliated to JNTUA, K. R. Palli Cross, Ananthapuramu, Andhra Pradesh, INDIA.

CORRESPONDENCE

Charan Sailaja

Department of Pharmaceutical Sciences, JNTUA, Ananthapuramu, Andhra Pradesh, INDIA.

charansailajaotpri@gmail.com

Received: 04-06-2023; Revised: 07-07-2023; Accepted: 14-08-2023.

Volume 14, Issue 1 · pp. 68-75 · 2023 · DOI: 10.5530/ijpi.14.1.10

ABSTRACT

Background: The work aimed to fabricate Loratadine (LRD) niosomes by employing a Box Behnken Design (BBD) and they were subsequently applied to transdermal patches utilizing BBD's solvent casting process.Materials and Methods: The prepared niosomes were assessed for their size, shape, zeta potential, and level of entrapment efficiency. The niosomal formulations that have been optimized were inserted into a patch system. Then, physico-chemical characteristics, and in vitro permeation studies were used to characterize each patch.Results: In comparison patches loaded with niosomal vesicles showed better drug release compared to the control patches. Niosomal patches had higher permeation than control patches, it was discovered. The surfactant in niosomes acts as a penetration enhancer, which helps to improve LRD permeation from niosomes.Conclusion: The work summarizes that the transdermal patches based on niosomes could efficiently deliver LRD medicines trans-dermally while preventing GIT side effects.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sailaja, C., & Bhupalam, P. K. (2023). A Box Behnken Design Optimized Nano Vesicular Transdermal Patch for Allergies. International Journal of Pharmaceutical Investigation, 14(1), 68-75. https://doi.org/10.5530/ijpi.14.1.10

    Copyright and licence

    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0