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Preparation and evaluation of chitosan microspheres containing nicorandil

1★, 2★ Corresponding author

  1. 1Research Scholar, Department of Pharmaceutics, Bhagwant University, Ajmer, Rajasthan, INDIA.
  2. 2A-One Pharmacy College, Enasan, Ahmedabad, Gujarat, INDIA.

CORRESPONDENCE

Keyur S Patel

Research Scholar, Department of Pharmaceutics, Bhagwant University, Ajmer, Rajasthan, INDIA.

keyur.pharma@gmail.com

Volume 4, Issue 1 · pp. 32-37 · 2014 · DOI: 10.4103/2230-973X.127738

ABSTRACT

Objectives: The objective of present study was to develop chitosan-based sustained release nicorandil microspheres to reduce the dosing frequency.Materials and Methods: The nicorandil-loaded chitosan microspheres were formulated by emulsion crosslinking method. A 32 factorial design was employed to study the infl uence of drug: Polymer ratio and volume of glutaraldehyde (GA) on percentage entrapment effi ciency, particle size, and % drug release at 8 h.Results: The entrapment effi ciency was found to be 41.67 ± 1.43-77.33 ± 1.97% and particle size range 65.67 ± 2.08-146.67 ± 2.18 μm. The batch CH5 showed 79.11 ± 2.23 and 96.21 ± 2.41% drug release at 8 and 12 h, respectively.Conclusions: Drug: Polymer ratio and volume of GA had signifi cant effect on % entrapment effi ciency, particle size, and % drug release. From the scanning electron microscopy (SEM) study observed that microspheres were spherical and fairly smooth surface. Fickian diffusion was the mode of drug release from nicorandil-loaded chitosan microspheres formulations.

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    Patel, K. S., & Patel, M. B. (2014). Preparation and evaluation of chitosan microspheres containing nicorandil. International Journal of Pharmaceutical Investigation, 4(1), 32-37. https://doi.org/10.4103/2230-973X.127738

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    © 2014 Author(s)

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