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In vitro characterization of statistically optimized quetiapine‑loaded self‑nanoemulsified systems with quality by design

1★, 2, 3, 4, 5★ Corresponding author

  1. 1Faculty of Pharmaceutical Sciences, JNTUA University.
  2. 2Division of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tirupati, Andhra Pradesh, INDIA.
  3. 3Department of Chemical Engineering, JNTUA College of Engineering, Anantapur, INDIA.
  4. 4Department of Pharmaceutics, SRM University, Chennai, Tamil Nadu, INDIA.
  5. 5Department of Pharmaceutics, CMR College of Pharmacy, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Jyothshna Devi Katamreddy

Faculty of Pharmaceutical Sciences, JNTUA University.

devijyothshna@gmail.com

Volume 8, Issue 1 · pp. 14-23 · 2018 · DOI: 10.4103/jphi.JPHI_9_18

ABSTRACT

Objective: To optimize and characterize quetiapine (QP)‑loaded self‑nanoemulsified drug delivery systems (SNEDDS) by 3‑factorial 3‑level Box–Behnken design (BBD) to improve the dissolution.Methods: Amounts of olive oil (X1), tween 80 (X2), and PEG 400 (X3) as independent factors, whereas % limpidity (Y1), self‑emulsification time (SET) (Y2), and drug released at 15 min (T15) (Y3) as responses were employed in BBD. Three‑dimensional response surface plots were run to understand the main interaction and quadratic effects of independent variables. Preliminary screening was carried out by equilibrium solubility and emulsification efficiency studies. Nanoemulsification region was recognized by pseudoternary plot.Results: Mean droplet size of optimized nanodispersion was 89.68 nm, electrokinetic potential was−27.2 mV and polydispersity index<1 and represented 94% of limpidity, 69 s of SET, and 93.4% of T15. Software‑generated model graphs (predicted versus actual and residual versus predicted) for all three responses were produced without outliers and thus indicated the adequacy of selected statistical model.Conclusion: This study explained the effectiveness of BBD in insights of formulation variables and quality of QP‑loaded nanoemulsified systems so as to enhance dissolution. As a result, BBD was a well‑suitable experimental design in predicting the responses of QP‑loaded liquid SNEDDS.

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    Katamreddy, J. D., Yalavarthi, P. R., Rao, D. S., Teja, S. S., & Battu, S. (2018). In vitro characterization of statistically optimized quetiapine‑loaded self‑nanoemulsified systems with quality by design. International Journal of Pharmaceutical Investigation, 8(1), 14-23. https://doi.org/10.4103/jphi.JPHI_9_18

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    © 2018 Author(s)

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