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Design and investigation of metformin hydrochloride–Indion‑254 complex for dispersible tablets

1,2, 2,3★, 1, 2★ Corresponding author

  1. 1Department of Pharmacology .
  2. 2School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies.
  3. 3Laboratory of Pharmaceutical Formulation Design and Development, School of Pharmacy Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, WEST INDIES.

CORRESPONDENCE

Madan Mohan Gupta

School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies.

mmingupta@gmail.com

Volume 8, Issue 1 · pp. 7-13 · 2018 · DOI: 10.4103/jphi.JPHI_3_18

ABSTRACT

Objective: Metformin is a first‑line agent for the treatment of Type 2 diabetes. The taste of metformin hydrochloride drug powder is bitter and its formulation are orally used. The objective of this study was to make a complex of metformin hydrochloride with Indion‑254 resin for the purpose of preparation of dispersible tablet.Materials and Methods: This study formulated metformin hydrochloride–Indion‑254 complexes with different proportion of resin with fixed amount of drug as well as mixed at varying speed which improved the flowability.Results: The resulted complex was investigated by the help of Fourier Transform- Infrared Spectroscopy, differential scanning calorimetry, and X‑ray diffraction which were used to confirm complexation and to differentiate its features from the individual ingredients and the physical mixtures of ingredients.Conclusion: The formulated metformin hydrochloride–Indion‑254 complex showed better drug loading as well as good release in mixed phosphate buffer in 200 ml.

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    Villarroel, A. S., Gupta, M. M., Pereira, L. M. P., & Gadad, A. K. (2018). Design and investigation of metformin hydrochloride–Indion‑254 complex for dispersible tablets. International Journal of Pharmaceutical Investigation, 8(1), 7-13. https://doi.org/10.4103/jphi.JPHI_3_18

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    © 2018 Author(s)

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