Volume 2, Issue 3

Ningning Yang

pp. 97-98 · DOI: 10.4103/2230-973X.104388 · 2012

Gene therapy has been investigated a lot in both basic research and clinical trials.[1] The first antisense oligodeoxyribonucleotide (ODN) drug, Vitravene (Fomivirsen), was approved by the United States Food and Drug Adm…

Shweta Handoo, Vandana Arora, Deepak Khera, Prafulla Kumar Nandi, Susanta Kumar Sahu

pp. 99-105 · DOI: 10.4103/2230-973X.104392 · 2012

The regulatory requirements of various countries of the world vary from each other. Therefore, it is challenging for the companies to develop a single drug which can be simultaneously submitted in all the countries for a…

Mohammad Tariq, Zeenat Iqbal, Javed Ali, Sanjula Baboota, Sushama Talegaonkar, Zulfiqar Ahmad, Jasjeet K Sahni

pp. 106-122 · DOI: 10.4103/2230-973X.104394 · 2012

Periodontitis is the most common localized dental inflammatory disease related with several pathological conditions like inflammation of gums (gingivitis), degeneration of periodontal ligament, dental cementum and alveol…

Shivang A Chaudhary, Aliasgar F Shahiwala

pp. 123-133 · DOI: 10.4103/2230-973X.104395 · 2012

Introduction: Common cold is the most frequently recurring disease in the world and is a leading cause of doctor visits and missed days from school and work. Cold reliever medicated chewing gum (MCG) will be a definitive…

Hitesh V Chavda, Rupal D Patel, Ishan P Modhia, Chhagan N Patel

pp. 134-139 · DOI: 10.4103/2230-973X.104396 · 2012

Introduction: Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure.Aim: The synthesis of SPH of poly (acrylamide-co-acrylic acid) and its …

Vidya Sabale, Sejal Vora

pp. 140-149 · DOI: 10.4103/2230-973X.104397 · 2012

Background: The purpose of this study was to develop microemulsion-based hydrogel formulation for topical delivery of bifonazole with an objective to increase the solubility and skin permeability of the drug. Materials a…

G Vijayaranga Vittal, R Deveswaran, S Bharath, BV Basavaraj, V Madhavan

pp. 150-156 · DOI: 10.4103/2230-973X.104398 · 2012

Introduction: Liquisolid technique is used in delivery of lipophilic and poorly water soluble drugs through oral route. It involves dissolving water insoluble drugs in nonvolatile solvents and converting into acceptably …

Tallapaneni Vishnuvardhan Rao, GB Kiran Kumar, Mohammed Gulzar Ahmed, Vedamurthy Joshi

pp. 157-161 · DOI: 10.4103/2230-973X.104399 · 2012

Aim and Background: The novelty of the present study was to control the release profile of matrix tablets of losartan potassium prepared by using different concentrations of chitosan and trisodium citrate as cross-linkin…

Shailesh T Prajapati, Parth B Patel, Chhagan N Patel

pp. 162-168 · DOI: 10.4103/2230-973X.104400 · 2012

Objective: Sumatriptan succinate is a selective 5-hydroxytryptamine-1 receptor agonist effective in the acute treatment of migraine headaches, having low bioavailability of about 15% orally due to first-pass metabolism. …