Volume 4, Issue 2

Original Research Article

1. Fast disintegrating crystalline solid dispersions of simvastatin for incorporation into orodispersible tablets

   Ritesh M Pabari, Asha Jamil, John G Kelly, Zebunnissa Ramtoola

   pp. 51-59 · DOI: 10.4103/2230-973X.133029 · 2014

   Aim: Spray dried solid dispersion (SDP) of crystalline simvastatin (SIM) in a fast disintegrating matrix of superdisintegrants was studied as a method to enhance SIM dispersibility, rheology, compactibility and compressi…

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2. Enhanced transdermal permeability of piroxicam through novel nanoemulgel formulation

   Bhavna Dhawan, Geeta Aggarwal, SL Harikumar

   pp. 65-76 · DOI: 10.4103/2230-973X.133053 · 2014

   Background: Piroxicam is a non-steroidal anti-infl ammatory drug belongs to BCS class II drugs having poor solubility and is associated with a number of undesirable side-effects on the stomach and kidneys in addition to …

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3. Conceptuation, formulation and evaluation of sustained release floating tablets of captopril compression coated with gastric dispersible hydrochlorothiazide using 23 factorial design

   Pathuri Lakshmi Sirisha, Govada Kishore Babu, Puttagunta Srinivasa Babu

   pp. 77-87 · DOI: 10.4103/2230-973X.133055 · 2014

   Ambulatory blood pressure monitoring is regarded as the gold standard for hypertensive therapy in non-dipping hypertension patients. A novel compression coated formulation of captopril and hydrochlorothiazide (HCTZ) was …

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4. Novel sustained release and swellable gastroretentive dosage form for ciprofl oxacin hydrochloride

   Vinay Dhananjay Gaikwad, Vishal Dadasaheb Yadav, Manish Dhananjay Gaikwad

   pp. 88-92 · DOI: 10.4103/2230-973X.133057 · 2014

   Introduction: The present study aims at developing a gastroretentive swellable and fl oating matrix tablet formulation of ciprofl oxacin hydrochloride (HCl) for the effective treatment of infections caused by susceptible…

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5. Design and optimization of bilayered tablet of Hydrochlorothiazide using the Quality-by-Design approach

   Yatin N Dholariya, Yogesh B Bansod, Rahul M Vora, Sandeep S Mittal, Ajinath Eknath Shirsat, Chandrashekhar L Bhingare

   pp. 93-101 · DOI: 10.4103/2230-973X.133058 · 2014

   Aim: The aim of the present study is to develop an optimize bilayered tablet using Hydrochlorothiazide (HCTZ) as a model drug candidate using quality by design (QbD) approach.Introduction and Method: The bilayered tablet…

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6. Development of co-processed excipients in the design and evaluation of atorvastatin calcium tablets by direct compression method

   Ravi Teja Pusapati, MVR Kalyan Kumar, Siva Satyanandam Rapeti, TEGK Murthy

   pp. 102-106 · DOI: 10.4103/2230-973X.133059 · 2014

   Introduction: Co-processed excipients were prepared to improve the process ability and effi cacy of commonly used excipients and to impart multi-functional qualities to the excipients and hence that the tablets with the …

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