International Journal of Pharmaceutical Investigation logo
Submit
International Journal of Pharmaceutical InvestigationACADEMIC PUBLISHING
Article

Formulation and evaluation of bucco-adhesive tablets of sumatriptan succinate

1★, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, INDIA.

CORRESPONDENCE

R Indira Prasanna

Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, INDIA.

indupharma2@gmail.com

Volume 1, Issue 3 · pp. 182-191 · 2011 · DOI: 10.4103/2230-973X.85971

ABSTRACT

Background: A novel aspiration in treatment of migraine, to provide greater therapeutic effect, overcome the side effects by complex therapeutic regimen and to improve patient compliance upon administering bucco-adhesive tablet formulations of sumatriptan succinate which have not been tested literally.Materials and Methods: This study was designed to develop a bucco-adhesive tablet containing sumatriptan succinate using blends of different bio-adhesive polymeric combinations such as hydroxy propyl methyl cellulose K4M, sodium carboxy methyl cellulose, and Carbopol 934P with a backing layer of ethyl cellulose by a direct compression technique. Tablets were subjected to physico-chemical parameters, swelling index, surface pH, ex vivo bioadhesive force, in vitro drug release, ex vivo drug permeation, and stability in saliva.Results: Good results were obtained in all the evaluated parameters. The drug release of all formulation follows zero- order kinetics by a diffusion mechanism type. Stability studies in human saliva, ex vivo buccal permeation studies by using sheep and porcine buccal mucosa were carried out for the optimized formulation (S4 CP:HPMC 3:1).Conclusion: The developed buccal drug delivery system containing sumatriptan succinate might be the alternative routes available to bypass the first pass metabolism and might be a milestone in the therapy of migraine and among all formulations S4 shows good controlled release results correlated with ex vivo permeation studies.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Prasanna, R. I., Anitha, P., & Chetty, C. M. (2011). Formulation and evaluation of bucco-adhesive tablets of sumatriptan succinate. International Journal of Pharmaceutical Investigation, 1(3), 182-191. https://doi.org/10.4103/2230-973X.85971

    Copyright and licence

    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0