International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 33Review Article
Tehzeeb T, Dhanabalan D
pp. 417-422 · DOI: 10.5530/ijpi.2020.4.74 · 2020
Recent progress in drug discovery in past decades reduced the high level of pain experienced due to infectious diseases by humans. A significant impact has been made on developing novel antimicrobial agents but is failin…
Pitchaimuthu Pandian
pp. 423-429 · DOI: 10.5530/ijpi.2020.4.75 · 2020
Heparin is used as anticoagulant for long period and also other activities both experimentally and clinically. The heparin is prepared by many methods namely enzymatic hydrolysis, chemical hydrolysis by removing the anti…
Original Article
Amit Vinayak Asati, Kishor Sahebrao Salunkhe, Machindra Jairam Chavan, Ravindra Bhausaheb Chintamani, Rudra Pratap Singh
pp. 430-436 · DOI: 10.5530/ijpi.2020.4.76 · 2020
Background: Solubility is an important physico-chemical factor affecting absorption of drug and its therapeutic effectiveness. One of the major problems responsible for the low turnout in the development of new molecular…
Ekramul Haque, Mohd Aamir Bin Riyaz, Sriram Shankar, Saqib Hassan
pp. 437-444 · DOI: 10.5530/ijpi.2020.4.77 · 2020
Objectives: The aim of this study was to isolate a potent biosurfactant producing bacterium and characterize the produced biosurfactant for its application in pharmaceutical, petrochemical, cosmetic and food industry. Me…
Johnson Stephin, Koland Marina
pp. 445-451 · DOI: 10.5530/ijpi.2020.4.78 · 2020
Introduction: Helicobacter pylori infection is strongly associated with chronic gastritis and duodenal ulcers which can benefit from gastro retentive delivery of clarithromycin. Objectives: The objective of this study wa…
S Agarwal, G Gautam
pp. 452-455 · DOI: 10.5530/ijpi.2020.4.79 · 2020
Background: The present investigation was held to develop vesicular ethosomal gel system for anti-hypertensive drug atorvastatin. Atorvastatin is a HMG-CoA reeducates inhibitor and utilized for minimizing cholesterol lev…
Prasad Suhas Kshirsagar, Darshana Sanjay Mote, Shriniwas Pramod Patil
pp. 456-459 · DOI: 10.5530/ijpi.2020.4.80 · 2020
Introduction: Andrographis paniculata is medicinal plant of family Acanthaceae, consists of bitter principles and traditionally used in treatment of several gastrointestinal diseases. To mask its bitter taste, it could b…
Garima Jain, Umesh K Patil
pp. 460-465 · DOI: 10.5530/ijpi.2020.4.81 · 2020
Objectives: The objective of the present study was to formulate, characterize and evaluate herbal formulations of Evolvulus alsinoides and Convolvulus pluricaulis against scopolamine-induced behavioral disturbances for A…
Zoya Shprakh
pp. 466-470 · DOI: 10.5530/ijpi.2020.4.82 · 2020
Background: Nitrosoureas are chemotherapeutic alkylating agents, widely used in the treatment of malignant diseases. One of them (streptozotocin) is the standard for the therapy of neuroendocrine tumours. We synthesised …
Naseeb Basha Shaik, Divya Shakelli, Lakshmi PK, Basava Rao VV
pp. 471-478 · DOI: 10.5530/ijpi.2020.4.83 · 2020
Objectives: The objective of the present study was to improve the absorption of dolutegravir sodium by developing oral proliposomal formulation. Methods: Proliposomal formulations were prepared by film deposition on carr…
Pankaj Bhatt, Suruchi Singh, Satish Kumar Sharma, Sani Rabiu
pp. 479-485 · DOI: 10.5530/ijpi.2020.4.84 · 2020
Objectives: Aim of the present research work is to prepared rapid mouth dissolving film of frovatriptan Succinate. Methods: Rapid Dissolving Film is prepared by Solvent casting method, hydroxypropyl methylcellulose E3 an…
Rathna Kumarasamy, Padavala Navyaka, Ekramul Haque
pp. 486-491 · DOI: 10.5530/ijpi.2020.4.85 · 2020
Objectives: In this study, bioengineered AgNPs (silver nanoparticles) from Spirulina platensis was used to counter the biofilm mediated virulence by Vibrio parahemolyticus. Methods: AgNPs were synthesized from crude Spir…
Amit Verma, Neetu Sachan, Kamla Pathak, Anurag Verma
pp. 492-499 · DOI: 10.5530/ijpi.2020.4.86 · 2020
Objectives: Natural polysaccharides are increasingly being used for diverse applications in drug delivery such as controlled release of drugs owing to their wide availability, renewability, biodegradability and biosafety…
Yeramanchi Sarah Sujitha, Yallamali Indira Muzib
pp. 500-505 · DOI: 10.5530/ijpi.2020.4.87 · 2020
Objectives: The objective of the present study was to increase the solubility of poorly soluble drug hesperidin and to increase the efficacy of the drug by loading hesperidin in emulsomal topical gel. Methods: Hesperidin…
Pathuri Raghuveer, Avula Prameela Rani
pp. 506-511 · DOI: 10.5530/ijpi.2020.4.88 · 2020
Aim: Self nano-emulsifying drug delivery system (SNEDDS) of candesartan cilexetil was explored to enhance its oral bioavailability. SNEDDS has tremendous potential in enhancing oral bioavailability of poorly aqueous solu…
Balamurugan Krishnan, Kirtimaya Mishra
pp. 512-518 · DOI: 10.5530/ijpi.2020.4.89 · 2020
Objectives: This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti- diabetic drugs (sitagliptin and metformin) in bulk and pharmaceutical formulations …
İshak Erik, Gözde Kılıç, Sevde Seher Yaylı, Gülşah Yılmaz, Kamil Coşkunçelebi, Nurettin Yaylı
pp. 519-525 · DOI: 10.5530/ijpi.2020.4.90 · 2020
Background: The present work was aimed to carry out volatile component analyzes in Vaccinium arctostaphlyos L., V. uliginosum L., V. vitis-idaea L. and V. myrtillus L leaf growing at different altitudes of the East Black…
Atchuta Ramakrishna Gudapati, Srinivasarao Pakalapati, Chidananda Swamy Rumalla, Benarji Patrudu Tammina
pp. 526-530 · DOI: 10.5530/ijpi.2020.4.91 · 2020
Objectives: Analytical methods are necessary for the field of pharmaceuticals to discover the drug, determination of drugs and metabolites in biological matrices. The present study aimed to develop liquid chromatography-…
Novel Development of RP-HPLC Method to Quantify Amoxicillin, Omeprazole and Rifabutin in Combination
Rama Kumar Kandula, Raja Sundararajan
pp. 531-536 · DOI: 10.5530/ijpi.2020.4.92 · 2020
Objectives: Helicobacter pylori infections are liable for most of the ulcers in the stomach and small intestinal. Talicia capsules was approved to be prescribed for the Helicobacter pylori infections. These capsules have…
HK Sundeep Kumar, Sujit Kumar Sahu, Jitendra Debata
pp. 537-541 · DOI: 10.5530/ijpi.2020.4.93 · 2020
Objectives: To develop a novel ultra-performance liquid chromatographic technique for the estimation of alectinib in a API and tablet. Methods: The chromatographic separation was achieved using DIKMA Endoversil (2.1 x 50…