International Journal of Pharmaceutical Investigation · Archive
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In this issue
Review Article
Thushara Bindu Dudala, Prasanna Raju Yalavarthi, Harini Chowdary Vadlamudi, Jyotsna Thanniru, Gowri Yaga, Naga Lakshmi Mudumala, Vivek Kumar Pasupati
pp. 149-155 · DOI: 10.4103/2230-973X.143112 · 2014
Both hydrophilic and lipophilic therapeutics can be delivered successfully into deep and peripheral tissues such as cerebrospinal fl uid and central nervous system by encapsulating them with crystalline lipids as liposph…
Original Research Article
Swati Gupta, Shailendra Kumar Singh, Priti Girotra
pp. 156-163 · DOI: 10.4103/2230-973X.143113 · 2014
Introduction: Silymarin is one of the best known hepatoprotective drugs, which is obtained from the seeds of Silybum marianum L., Family: Asteraceae or Compositae. The plant has traditionally been used for centuries as a…
Raad A. Kaskoos
pp. 164-173 · DOI: 10.4103/2230-973X.143114 · 2014
Introduction: Management of ocular surface disease by conventional formulation is limited by poor residence of drug at cul-de-sac of eye. To overcome this limitation, prolonged released mucoadhesive chitosan (CS)–dextran…
Formulation and evaluation of fast dissolving tablet containing domperidone ternary solid dispersion
Dasharath M. Patel, Sweeti P. Patel, Chhagan N. Patel
pp. 174-182 · DOI: 10.4103/2230-973X.143116 · 2014
Introduction: Fast dissolving tablet containing domperidone ternary solid dispersion was developed to improve the dissolution of drug and stability of solid dispersion. Materials and Methods: Binary and ternary solid dis…
J. Jayasree, S. Sivaneswari, G. Hemalatha, N. Preethi, B. Mounika, S. Vasudeva Murthy
pp. 183-188 · DOI: 10.4103/2230-973X.143118 · 2014
Objectives: The objective of the present work was to formulate and to characterize controlled release matrix tablets of losartan potassium in order to improve bioavailability and to minimize the frequency of administrati…
Chukwuma O. Agubata, Salome A. Chime, Franklin C. Kenechukwu, Ifeanyi T. Nzekwe, Godswill C. Onunkwo
pp. 189-194 · DOI: 10.4103/2230-973X.143120 · 2014
Introduction: The purpose of this study was to improve the solubilization, bioavailability, and permeability of hydrochlorothiazide (HCTZ) by the formulation and characterization of HCTZ solid lipid microparticles (SLMs)…
Parul Jaiswal, Geeta Aggarwal, Sasidharan Leelakumari Harikumar, Kashmir Singh
pp. 195-206 · DOI: 10.4103/2230-973X.143123 · 2014
Objectives: Self-microemulsifying drug delivery system (SMEDDS) and solid-SMEDDS of telmisartan was aimed at overcoming the problems of poor solubility and bioavailability. Methodology: The formulation strategy included …
Poluri Koteswari, Suvarnala Sunium, Puttugunta Srinivasababu, Govada Kishore Babu, Pinnamraju Durga Nithya
pp. 207-214 · DOI: 10.4103/2230-973X.143125 · 2014
Introduction: Epilepsy is a serious neurological disorder. Lamotrigine is an alternative to lithium for the treatment of epilepsy, and its oral bioavailability is 98%; however, its poor aqueous solubility hinders its ora…
Suresh G Killedar, Ashwini B Nale, Harinath N More, Sameer J Nadaf, Anuja A Pawar, Umarfarukh S Tamboli
pp. 215-225 · DOI: 10.4103/2230-973X.143128 · 2014
Introduction: Present work, is an effort toward exploring the potential of Cassia fi stula Linn. seed gum as an extended release polymer and laxative. While, C. fi stula pulp polymer has evaluated as suspending agent. Ma…
Jayesh K. Jethava, Gaurang K. Jethava
pp. 226-232 · DOI: 10.4103/2230-973X.143131 · 2014
Introduction: The eye is an interesting organ. The tear fl ow and blinking refl ex maintains a good environment and removes foreign material from the eye. Several polymeric systems have been used to fabricate ocular inse…