International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 30Review Article
Tanu Raj Dulal, Deepak Kumar Jha, Saroj Kumar Sah, Mehdi Fathima
pp. 1-9 · DOI: 10.5530/jphi.20251571 · 2024
Dendritic Cells (DCs) play a pivotal role in the immune system, acting as sentinels that capture, process and present antigens to T cells, thus initiating and regulating immune responses. Activation of DCs stands at the …
Puja Ganeshrao Maldhure, Anita Wanjari, Kirti Naharwal
pp. 10-18 · DOI: 10.5530/jphi.20251739 · 2024
Histamine is found in a variety of bodily fluids, platelets, leucocytes, basophils and mast cells in the human body. Mast cells and circulating basophiles store the majority of histamine. Moreover, histamine functions as…
Deepika Dyapenahalli Umesh, Purushotham Karadigere Nagaraj, Likhith Kumar Karadigere, Madhu Bommenahalli Krishnegowda, Thoppalada Yunus Pasha
pp. 19-29 · DOI: 10.5530/jphi.20250020 · 2024
Cancer is one of the world’s most prevalent causes of death; there is a constant need to find novel treatment medications with increased efficacy and reduced adverse effects. Cancer is a complex group of diseases charact…
Fahad Raad Salim Altalib, Omar A Hamid
pp. 30-48 · DOI: 10.5530/jphi.20250057 · 2024
In recent decades targeted drug delivery has obtained a significant interest for its ability to enhance therapeutic efficacy and reduce side effects of the drugs. Among them, colon-targeting drug delivery systems have be…
Kaviya Suresh, Devasena Srinivasan, Venkatesan Palanivel, Anbarasan Balu
pp. 49-56 · DOI: 10.5530/jphi.20250082 · 2024
Nanocochleates, lipid-based nanostructures inspired by the cochlea’s spiral structure, have developed as talented candidates for advanced drug delivery systems and therapeutic applications. Their special design, which co…
Mahalakshmi Devaraji, Lokeshvar Ravikumar
pp. 57-66 · DOI: 10.5530/jphi.20251769 · 2024
In recent years, biomedical research has resulted in innovative methods for precisely altering genomes, advancing personalized diagnostics and therapeutics through genetic engineering. The Clustered Regularly Interspaced…
Hellen Yayra Dzoagbe, Anup Sanjay Shende, Mujibhullah Sheikh, Mrunal Deshmukh
pp. 67-77 · DOI: 10.5530/jphi.20251862 · 2024
As it adds so many advantages to the finished formulations, excipient utilised in pharmaceutical dosage forms is a special and important ingredient that is just as important as the API. Improving API absorption and bioav…
MFF Rukshana, Mudiyanselage Imalka Upamali Kumari Tennakoon
pp. 78-85 · DOI: 10.5530/jphi.20251792 · 2024
Health entrepreneurship has emerged as a dynamic force shaping the landscape of healthcare delivery, with a particular focus on the pharmaceutical sector. This mini-review aims to investigate and present success stories …
Maryam Musleh Althobiti
pp. 86-102 · DOI: 10.5530/jphi.20250002 · 2024
Major molecular, physical as well as cellular changes inside their host tissues are enthused by the tumor cells. The evolving TME is an active and multifaceted system. The structure of the TME differs amongst the categor…
Original Article
Bariki Rajasekhar, Haranath Chinthaginjala
pp. 103-112 · DOI: 10.5530/jphi.20251733 · 2024
INTRODUCTION: The benefit of systemic Donepezil absorption by transdermal patches is that they avoid hepatic first-pass metabolism. They make it possible for drugs to be gradually and carefully released into the bloodstr…
Ramakrishna Chintakunta, Lalitha Suresh, Rutushree Amar, Nisarga Mahadevaiah, Lisha Mallesh, S Jeevan Prasad
pp. 113-121 · DOI: 10.5530/jphi.20251753 · 2024
Background: Design synthesis of Acetaminophen-chalcone conjugates and finding the in silico studies and characterisation of compounds. Determination of biological activity mainly emphasise on Antibacterial activity. Chal…
Repollu Maddileti, Haranath Chinthaginjala
pp. 122-130 · DOI: 10.5530/jphi.20251755 · 2024
Background: The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, …
Neelima Ganzi, Savitha Rajapur Sanathan, Subhash Chandra Ballekere Jayaram, Easwaran Vigneshwaran
pp. 131-137 · DOI: 10.5530/jphi.20251760 · 2024
Background: Medical Intensive Care Unit (MICU) admitted patients have complex drug regimens, serious underlying diseases which increase the risks of Medication-Related Problems (MRP). The study aims to identify, characte…
Prashant Nayak, Rompicherla Narayana Charyulu, Alandur Veena Shetty
pp. 138-158 · DOI: 10.5530/jphi.20251766 · 2024
Background: By increasing drug stability and water solubility, cycle duration, rate of absorption into target cells or tissues, and reducing enzymatic degradation, Nano Drug Delivery Systems (NDDS) improve the safety and…
Ishu Tyagi, Kandasamy Nagarajan, Snigdha Bhardwaj
pp. 159-169 · DOI: 10.5530/jphi.20251789 · 2024
Background: Efavirenz is a widely used antiretroviral medication for managing HIV infection, known for its role as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). By targeting and inhibiting the reverse transcr…
Sanket Keshav Tambe, Rohit Jaysing Bhor, Shubham Balasaheb Mhaske, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Neha Shyam Bora, Vaijanti Ashok Medge, Akanksha Kailas Nirmal
pp. 170-181 · DOI: 10.5530/jphi.20251795 · 2024
Background: GPCRs are among the most effective therapeutic target families. They have undergone a transition from ligand screening at random to knowledge-driven drug design. We are seeing first-hand the enormous strides …
Mayur Sitaram Gaikwad, Rohit Jaysing Bhor, Mahesh Hari Kolhe, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Neha Shyam Bora, Vaijanti Ashok Medge, Akanksha Kailas Nirmal
pp. 182-190 · DOI: 10.5530/jphi.20251804 · 2024
Background: It was a heterocyclic hydrocarbon whose molecular structure has some fundamental structural features. In this study, we synthesise eleven different imidazolidine-2,4-dione derivatives that have convulsive pro…
Rohit Jaysing Bhor, Harshada Sudhakar Aher, Sanket Keshav Tambe, Mahesh Hari Kolhe, Neha Shyam Bora, Vaijanti Ashok Medge, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Akanksha Kailas Nirmal
pp. 191-198 · DOI: 10.5530/jphi.20251822 · 2024
Background: Five-membered heterocycle with one neighbouring nitrogen atoms is present in the indole nucleus. Heterocyclic substances feature two adjacent benzene and pyrrole ring atoms. Indoles are heterocyclic compounds…
Taranga Jyoti Baruah, Sanathoi Tongbram, Pratyashi Bora, Shivani Priya, Langlen Meinam, Sanjenbam Kabita
pp. 199-208 · DOI: 10.5530/jphi.20251798 · 2024
Background: Xanthine oxidase and tyrosinase are enzymes involved in various functions in the body. Tyrosinase and xanthine oxidase have high activity levels in various diseases like gout hyperpigmentation and neurodegrad…
Palanisamy Pethappachetty, Kavya Thirupathi, Phagalavan Moorthy, Mohan Kumar, Manivasakam Prakash, Anandharaj Govindharaj
pp. 209-218 · DOI: 10.5530/jphi.20251622 · 2024
Aim/Background: This research explores the pharmaceutical industry’s operations management, focusing on regulatory-based operation management for parenteral preparations. Materials and Methods: The study utilizes a compr…