International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 41Review Article
Mohomed Faizal Umair Ahamed, Gothai Sivapragasam, Nanthini Sridewi Appan
pp. 1065-1072 · DOI: 10.5530/ijpi.20250125 · 2025
This review offers an overview of the crucial role microglia play in neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. It also delves into the therapeutic potential of natural produc…
Abdulhadi M Abdulwahed
pp. 1073-1085 · DOI: 10.5530/ijpi.20250384 · 2025
This review aims to discuss the progress made in targeted drug delivery of small molecules in breast cancer, as well as the methods that can be used to increase the accuracy of the treatment and reduce the overall toxici…
Gopinath Govindarajan, Ranganadhareddy Aluru
pp. 1086-1095 · DOI: 10.5530/ijpi.20250277 · 2025
In biopharmaceutical manufacturing chromatography technique has been the backbone of purification process. As bioprocessing has advanced, a growing trend has emerged toward gaining a thorough understanding of the fundame…
Rajendran Akash, Sathiyamoorthy Rajesh, Bhuvaragavan Devishree, Karthikeyan Aravind, Selvaraj Deepa, Kesavan Sathesh Kumar
pp. 1096-1107 · DOI: 10.5530/ijpi.20250319 · 2025
This review article provides a comprehensive examination of collagen-loaded dental applications, focusing on collagen dental plugs used for socket preservation and tissue regeneration following tooth extraction. It explo…
Ajay Charan, Lita Susan Thomas, Vaishali Bambal, Vanaja Kenchappa, Anju Jose
pp. 1108-1121 · DOI: 10.5530/ijpi.20250508 · 2025
Ventilator-Associated Pneumonia (VAP) is a prevalent and serious hospital-acquired infection occurring in critically ill patients who have been mechanically ventilated for over 48 hr. It is primarily caused by Gram-negat…
Mahavir M. Sharma, Harshkumar Brahmbhatt, Priyanka Shah, Ujjval P. Vaghela
pp. 1122-1129 · DOI: 10.5530/ijpi.20250488 · 2025
This review delineates the primary objectives of Quality by Design (QbD) and provides an in-depth exposition of its foundational concepts. The core components of QbD include: (1) the establishment of a comprehensive cont…
Venkateswara Raju Kalidindi, Gutturu Dheeraj Balaji, Uda Mahalakshmi, Sirilla Dinesh Babu, Badugu Priyanka, Tekumudi Vasantha Naga Lakshmi, Lakshmi Prasanthi Nori
pp. 1130-1143 · DOI: 10.5530/ijpi.20250005 · 2025
Decentralized Clinical Trials (DCT) utilize digital health technologies, remote monitoring, and telehealth, eliminating the need for traditional in-person visits to clinical sites. This model provides significant benefit…
Lakshmi Prasanthi Nori, Ketha Bhavani, Yamini Satya Sri, Gangomolu Pujitha, Kiran Manda, Sudarshan Rao Nagineni, Kalidindi Venkateswara Raju
pp. 1144-1152 · DOI: 10.5530/ijpi.20250006 · 2025
Materiovigilance refers to the system of safety monitoring and performance of medical devices after being placed on the market and involves collecting, analyzing, and responding to reports of malfunctions, adverse events…
Jiafeng Li, Tiefeng Jin, Meihua Zhang
pp. 1153-1159 · DOI: 10.5530/ijpi.20250329 · 2025
The "Four New" initiatives have emerged as a pivotal framework for advancing higher education in China. Among these, the promotion of New Medical Sciences not only meets the evolving demands of the contemporary era but a…
Sagar Mysore Shivakumar, Rashmi Nelligare Gopalakrishna
pp. 1160-1167 · DOI: 10.5530/ijpi.20250255 · 2025
Endophytic fungi have engrossed the most attention owing to their prospect of being a source of many bioactive compounds. These fungi are regarded as effective producers of valuable metabolites, such as antibacterial, an…
Original Article
Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Abida Haripriya Rammohan, Dharshini Sagadevan, Udhayakumar Thangavelu
pp. 1168-1174 · DOI: 10.5530/ijpi.20250175 · 2025
Objectives: This study centers on the development and assessment of a facial serum fortified with the innate antioxidant’s resveratrol and quercetin, to address skin aging and acne. Materials and Methods: The serum was c…
Harshitha Nagaraj, Kusu Susan Cyriac, Deepak Kumar Jha
pp. 1175-1183 · DOI: 10.5530/ijpi.20250149 · 2025
Background: Inflammation is the body's innate defence mechanism that is initiated in reaction to injury or on exposure to detrimental agents. Plumeria alba Linn, a small laticiferous tree rich in phytochemicals and antio…
Amaresh Chandra Sahoo, Sujit Dash, Prabhat Kumar Sahoo, Minaketan Sahoo
pp. 1184-1194 · DOI: 10.5530/ijpi.20250206 · 2025
Background: Emulgel is a combination of gel and emulsion. Drugs are first incorporated into an emulsion and then the conventional emulsion is transferred into an emulgel by using a gelling agent. Objectives: To formulate…
Ang Wan Yi, Mukhri Hamdan, Giribabu Nelli
pp. 1195-1205 · DOI: 10.5530/ijpi.20250416 · 2025
Background: Male infertility is associated with vitamin D deficiency, and much evidence suggests ways to correct this deficiency to restore fertility. Vitamin D supplementation in men significantly improved fertility and…
Gobu, Emmanuel, Daniel Sundar Singh, Prakashraj Elumalai, Roshan Nawaz Ayas, Solai Ganesh Subburaj
pp. 1206-1213 · DOI: 10.5530/ijpi.20250299 · 2025
Background: Cardiovascular diseases are increasingly becoming a major cause of morbidity and mortality around the world. About half of the deaths due to non-communicable diseases are attributed to some form of cardiovasc…
Rajendran, Sudesh Raj, Tejas, Jayakumar, Sneha, Reethi
pp. 1214-1226 · DOI: 10.5530/ijpi.20250211 · 2025
Background: Ashwagandha (Withania somnifera), traditionally valued for enhancing stress resilience, is known for its neuroprotective and antioxidant effects. This study explores the Orgaheal™ Ashwagandha with Valerian Ro…
Monish Mukul Das, Sayan Chakraborty, Avijit Mondal, Tapas Guha
pp. 1227-1234 · DOI: 10.5530/ijpi.20250261 · 2025
Background: Staphylococcus aureus is a gram-positive pathogen which contributes community-associated and nosocomial serious diseases and it has become resistant to various antimicrobials. Owing to rapid advent and contin…
Rashed Mohammed Alghamdi
pp. 1235-1248 · DOI: 10.5530/ijpi.20250268 · 2025
Background: Non-Small Cell Lung Cancer (NSCLC) epitomizes 85% of lung cancer cases with poor survival rates. Understanding molecular mechanisms through gene expression analysis is important for developing real treatments…
Belum Jyoshna, Vadlavari Pavan Chandu, Valmiki Uday Sai, Gaddam Vamsidhar Reddy, Bandi Sai Supraja, Caleerappa Ravi Shankar, Akkiraju Sudheer
pp. 1249-1253 · DOI: 10.5530/ijpi.20250300 · 2025
Background: According to WHO Drug Utilization research, it is defined as "the marketing, distribution, prescription, and use of drugs in a society, with special emphasis on the resulting medical, social, and economic con…
Sandeep Subhash Sagare, Srinivas Prasad Buduru, Kavita Sutagatti, Zeba Mulla
pp. 1254-1260 · DOI: 10.5530/ijpi.20250306 · 2025
Background/Purpose: Anemia poses a significant public health challenge, particularly in developing nations. Indian government has initiated several programs aimed at reducing the prevalence of anemia, such as providing i…