International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 33Review Article
Jayant Kumar, Ajmera Ramkishan, Madhugiri Prakash Venkatesh
pp. 1-9 · DOI: 10.5530/ijpi.14.1.1 · 2023
Bringing a new healthcare product to market can be challenging, especially when navigating the complex regulatory requirements of different countries. The approval process can be a maze of differing regulations, but this…
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Jayasheela Hiremath, Abhishek BJ, Saurav Raj, Megha Hegde, Dhananjay Tikadar, Raviteja Somashekhar Kanavi, Rohith Javali Veeresh
pp. 10-15 · DOI: 10.5530/ijpi.14.1.2 · 2023
Background: The drug Finerenone, a selective the drug mineralocorticoid receptor antagonist, indicated for Chronic Kidney Disease (CKD) and Type 2 Diabetes. Recent researchers also found add on role in the management of …
Himangshu Deka, Ananta Choudhury, Jahnabi Sarmah, Debgopal Ganguly, Rosamund Jyrwa, Dhiraj Baishya, Nurjamal Houque
pp. 16-22 · DOI: 10.5530/ijpi.14.1.3 · 2023
Diabetes mellitus is a global health concern resulting in significant morbidity and mortality. Till today there is no known cure available for the condition. The extended treatment schedule, unfavorable side effects of c…
Sepideh Kianian, Rozhin Moloudpour Toulakani, Fatemeh Zisti, Davoud Balarak, Shaziya Haseeb Siddiqui, Morteza Khodadadi Saloot
pp. 23-29 · DOI: 10.5530/ijpi.14.1.4 · 2023
Background: The presence of antibiotic residues in water is a matter of concern for both public health and the environment, owing to the phenomenon of antibiotic resistance. One of the Advanced Oxidation Processes (AOPs)…
Rajesh Hadia, Vishal Singh, Nidhi Solanki, Shiwanand Sharma, Varunsingh Saggu, Cyril Sajan, Rahul Trivedi, Sunil Kardani, Sunil Baile, Hemraj Singh Rajput, Rajesh Maheshwari
pp. 30-38 · DOI: 10.5530/ijpi.14.1.5 · 2023
Aim/Background: The Cytochrome P450 (CYP) enzyme family, consisting of 57 distinct genes, plays a pivotal role in various biological processes. These genes encode enzymes with multifaceted functions, impacting vital proc…
Shriniwas Pramod Patil, KV Ramanath, Hemant Kumar Jain, Charu Pandya, Bhagyashree Pawar, Seema V Pattewar
pp. 39-47 · DOI: 10.5530/ijpi.14.1.6 · 2023
Since long back, many Lycopodiaceae or Huperziaceae plants species like Lycopodium clavatum L. serratum, Huperzia serrata, H. carinata, Phlegmariurus squarrosus and P. henryi are being traditionally used in treatment of …
Praveen Halagali, Rohan Singadi, Hunsur Ranganath Arjun, Gundada Sivaraj Rakshanaa, Salini Parameswaran Nair, Prashant Halagali, Preethi Somanna
pp. 48-54 · DOI: 10.5530/ijpi.14.1.7 · 2023
Natural elements from nature along with their bioactive components are being extensively studied in recent times for their therapeutic efficacy in treating a variety of degenerative disorders. These diseases are specific…
Original Article
Amira Nabila Mat Roof, Richard Johari James, Salfarina Ramli, Boonchoo Sritularak, Pornchai Rojsitthisak, Hasseri Halim
pp. 55-61 · DOI: 10.5530/ijpi.14.1.8 · 2023
Background: The imbalance level of Reactive Oxygen Species (ROS) in the body can lead to oxidative stress in cells, resulting in the progression of chronic diseases. Fargesin, a bioactive lignan found in Flos magnoliae, …
Akshay Shankpal, V. P. Yogita, R. Chinmayee, Santhosh Reddy, P. K. Lakshmi
pp. 62-67 · DOI: 10.5530/ijpi.14.1.9 · 2023
Background: This study aimed to establish and promote drug information services for healthcare professionals and patients in a tertiary care hospital, and to assess the level of awareness and utilization of the center. M…
Charan Sailaja, Pradeep Kumar Bhupalam
pp. 68-75 · DOI: 10.5530/ijpi.14.1.10 · 2023
Background: The work aimed to fabricate Loratadine (LRD) niosomes by employing a Box Behnken Design (BBD) and they were subsequently applied to transdermal patches utilizing BBD's solvent casting process.Materials and Me…
Gaurav Singh Sikarwar, Mukesh Kumar Gupta
pp. 76-88 · DOI: 10.5530/ijpi.14.1.11 · 2023
Aim: The study’s goal was to develop and characterize a new type of Fenoprofen tablet that can float. Materials and Methods: Research on the drug’s performulation was carried out to evaluate its organoleptic qualities, s…
Piyusha Kolhe, Rahul Godge, Hrishikesh Ghorpade, Gaurav Dhanvate, Anurag Nalawade
pp. 89-100 · DOI: 10.5530/ijpi.14.1.12 · 2023
Background: Antibiotic resistance is a growing concern, and the development of new anti-bacterial agents is crucial. 2-aminophenyl-2-(2,4,5-triphenylimidazole) derivatives have shown potential as anti-bacterial agents in…
Nandini Rebbbaniboni, Seetha Mahithavani, Gayatri Somayala, Malladi Venkata Srihari Lakshman, Jahnavi Bandla
pp. 101-106 · DOI: 10.5530/ijpi.14.1.13 · 2023
Background: The primary objective of this research was to establish a spectrophotometric technique to quantitatively analyze the concentration of favipiravir in both its pure form and pharmaceutical preparations using br…
Thriveni Raunak Salian, Nadira Noushida, Benachakal Honnegowda Jaswanth Gowda, Manodeep Chakraborty, Sindhu Priya Enumadisetty Srinivasulu, Mohammed Gulzar Ahmed
pp. 107-116 · DOI: 10.5530/ijpi.14.1.14 · 2023
Background: Resveratrol (3,4,5-trihydroxystilbene), a polyphenol derived from plant sources, despite its cardioprotective properties, has limited therapeutic impact due to its low in vivo bioavailability and rapid metabo…
Himanshu Sharma, Phool Chandra
pp. 117-126 · DOI: 10.5530/ijpi.14.1.15 · 2023
Background: Many parts of the brain experience excruciating pain as a result of Alzheimer's disease, a form of dementia. Cognitive processes and neuropsychiatric regulation are disrupted by the numerous neuropathologies …
Anjana Chandran, Marina Koland, Sindhoor Shridharan Mulleria
pp. 127-134 · DOI: 10.5530/ijpi.14.1.16 · 2023
Background: Acyclovir is a widely used anti-viral drug that has low bioavailability when administered orally and is also difficult to administer parenterally due to its inherent solubility limitations. Buccal administrat…
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Akash Chathamvelli, Kadambari Patil, Anirudh Pai, Aditi Baadkar
pp. 135-140 · DOI: 10.5530/ijpi.14.1.17 · 2023
Background: Tuberculosis (TB), a highly contagious and dangerous disease, impacts millions globally, with India topping the list of affected countries. The study aimed to evaluate the knowledge, attitude, practice, and m…
Santosh B Patil, Pramod C Gadad
pp. 141-150 · DOI: 10.5530/ijpi.14.1.18 · 2023
Background: Genetic metabolic illnesses called Glycogen Storage Disease type I (GSD I) are caused due to abnormalities in the glucose-6-phosphatase enzyme complex involved in the metabolism of glycogen. Objectives: The c…
Neha Gaikwad, Charushila Bhangale, Sangita Bhandare
pp. 151-159 · DOI: 10.5530/ijpi.14.1.19 · 2023
Objectives: The key objective of this work is to establish a stability-indicating UHPLC technique for measuring amlodipine and enalapril maleate in bulk and pharmaceutical formulations Materials and Methods: The mobile p…
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Abhishek B J, Amisha Netalakar, Bhoomika S K, Namratha D, Tahameen K Kurabanavar
pp. 160-164 · DOI: 10.5530/ijpi.14.1.20 · 2023
Background: Cardiovascular Disease (CVD) is commonly known as disease of heart of blood vessels and is typically composed of fatty deposits. Heart attack and Heart failure are caused by the high levels of fatty tissues b…