International Journal of Pharmaceutical Investigation · Archive
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In this issue
1–20 of 42Review Article
Lakshmi Prasanthi Nori, Jyothirmai Malla, Rama Rao Vadapalli, Brahmaiah Bonthagarala, Praveen Kumar Dannaram, Kalidindi Venkateswara Raju
pp. 675-688 · DOI: 10.5530/ijpi.20250137 · 2025
Due to the imbalanced patient-to-healthcare professional ratios, the increased workload for those who provide care, different adverse reactions of modern medicine, the inability to completely cure long-term ailments, exp…
Akram Ahmed Aloqbi
pp. 689-697 · DOI: 10.5530/ijpi.20250217 · 2025
Background: A compound called zerumbone found in gingers rhizome has demonstrated potential in fighting cancer due to its beneficial effects on the body. This thorough examination delves into how zerumbone works to comba…
Bhavya Ekambaram, Swetha Suresh, Jerphene Franklin John, Nithish Kumar Jothi Kamaraj
pp. 698-702 · DOI: 10.5530/ijpi.20250210 · 2025
Background: Kounis Syndrome (KS) or allergic myocardial infarction is a rare, complicated Coronary Artery syndrome (CAD) which develops concurrently with an allergy or hypersensitivity reaction. It is also termed as Alle…
Saket Mishra, Priyanka Shukla, Deshraj Shyamkant Chumbhale, Pijush Dutta, Dhakshnamoorthy Vellingiri, Ruchi Tiwari
pp. 703-724 · DOI: 10.5530/ijpi.20250244 · 2025
In today’s modern world, there is a rapid increase in the control and systemic administration of drugs through the oral route, because of its various advantages like high patient compliance, easy dose administration and …
Netala Silvia, Atla Srinivasa Rao, Yalla Kranthi, Gangolu Yohan, Darisi Saketh, Gajula Meghamala, Kolli Prabhanjan Kumar
pp. 725-739 · DOI: 10.5530/ijpi.20250192 · 2025
Polyphenols are one of the well-known phytochemicals and exist as secondary metabolites in natural products and show numerous physiological effects in all the living organisms due to the presence of simple phenols, aroma…
Vivek Reddy Murthannagari, Jeswanth Raj Nagarajan, Ganesh Gonna Nandi Krishnan, Karthikesavan Ponmurugesan, Hemalatha Thavani Devaraj, Krushika Jani
pp. 740-747 · DOI: 10.5530/ijpi.20250202 · 2025
Surgical intestinal wound healing is a significant cellular process managed by several cellular and molecular factors. The present review aims to focus on the evolution of medical device bandages that can help improve th…
S Revathy, R Nathiya, K Shoba
pp. 748-752 · DOI: 10.5530/ijpi.20250185 · 2025
The annual plant fenugreek (Trigonella foenum graecum), which is indigenous to southern Europe and Asia, has white blossoms and hard, yellowish brown, angular seeds. It has long been valued for its nutritional content in…
T C Swathi Ramesh, Savitha R Sanathan, S S Kiron, M S Srikanth
pp. 753-758 · DOI: 10.5530/ijpi.20250232 · 2025
The development of the HPV vaccine represents a groundbreaking achievement in the history of vaccine research. These vaccines, a pioneering category, effectively prevent infection by sexually transmitted microorganisms t…
Buchaiahgaripalli Yamuna, Vepamani Siva Sai Bharath Kumar, Kateregga Ismael, Nawaz Mahammed, Sabbella Sameera Reddy, Sunkesula Shahid, Gangaigari Sowmya, Lingala Tharun Kumar Reddy, Bellam Raj Kumar
pp. 759-769 · DOI: 10.5530/ijpi.20250248 · 2025
Quantum Dots (QDs), semiconductor nanoparticles, exhibit unique optical properties like excellent photostability, high brightness, and size-tuneable emission wavelengths due to quantum confinement. Their broad absorption…
Narendra Pentu, Gaddam Namitha, Kalluru Udaya Chandrika, Kolapuri Abhinav Ram, Venkata Rajesham Vallala, Ashok Morsu, Tadikonda Rama Rao
pp. 770-776 · DOI: 10.5530/ijpi.20250171 · 2025
Cancer is not a single disease, it is a multifaced malignant tumor, having ability to develop in any part of our body and it can spread to the distant regions with the high-end cell proliferation within short duration of…
Shilpa Clara Joseph, Ramaswamy Subramanian, Shiva Prasad, Mahabaleshwar Mamadapur
pp. 777-782 · DOI: 10.5530/ijpi.20250264 · 2025
Background: Vonoprazan is a novel PCAB and the first in its class to receive US FDA approval for the treatment of H. pylori infection and gastric acid-related disorders. It binds directly to the proton pumps, blocking th…
Deepak Kumar Jha, S. Manasa, Kusu Susan Cyriac, Raveena Shree R
pp. 783-792 · DOI: 10.5530/ijpi.20250174 · 2025
Oral Mucositis (OM) is a painful inflammation often resulting from cancer therapies like chemotherapy and radiotherapy. OM manifests as ulcers that can make eating and speaking difficult and increase infection risk. Curr…
Megha Roy, Mujibullah Sheikh, Darshan Telange
pp. 793-808 · DOI: 10.5530/ijpi.20250182 · 2025
Iron Oxide Nanoparticles (IONPs) are exciting technology in cancer therapy that represents agents with a unique combination of super paramagnetism, biocompatibility and the capability for surface functionalization toward…
Mujibullah Sheikh, Pollob Roy, Pranita Jirvankar
pp. 809-822 · DOI: 10.5530/ijpi.20250203 · 2025
The review article deals with the possibility of the use of Antibody-Drug Conjugates (ADCs) for the treatment of rheumatic diseases. The introduction emphasizes the difficulty of chronic autoimmune diseases’ management a…
Molika Malpani, Pranita Jirvankar
pp. 823-836 · DOI: 10.5530/ijpi.20250239 · 2025
Soft robotics is a rapidly emerging area in healthcare and biomedical applications due to recent developments in functional materials and fabrications. This review will focus on the position that soft robotics have in me…
Lokeshvar Ravikumar, Ramaiyan Velmurugan, Patibandla Jahnavi, Pradeep Vidiyala, J Pavan Kumar, A Rahul, P Bhuvaneshwaran
pp. 837-848 · DOI: 10.5530/ijpi.20250189 · 2025
The present study focuses on the nanoscale formulation technique for pharmacological agent delivery, avoiding the shortcomings of conventional protocols, such as rapid pharmaceutical clearance, limited site-specific accu…
Zainab Eassa Jassim, Nawal A. Rajab
pp. 849-857 · DOI: 10.5530/ijpi.20250305 · 2025
Polymeric micelles which are formed by the self-assembly of amphiphilic copolymers, are distinguished among the other forms of nanostructured carriers due to their restricted size distribution, conformation, and surface …
Rajesh Hadia, Rahul Trivedi, Sunil Kardani, Sunil Baile, Cyril Sajan, Varunsingh Saggu, Hemrajsingh Rajput
pp. 858-863 · DOI: 10.5530/ijpi.20250310 · 2025
The prevalence of both Age-related Macular Degeneration (AMD) and Diabetic Macular Edema (DME), are notably high, given the significant morbidity they generate and the burden placed on healthcare systems globally. Advanc…
Original Article
Akram Ahmed Aloqbi
pp. 864-872 · DOI: 10.5530/ijpi.20250216 · 2025
Background: Cancer, particularly breast cancer, remains a major global health challenge, prompting ongoing research into novel therapeutic targets. This study focuses on Aurora A protein kinase, a serine/threonine kinase…
Prerana Badrinath Jadhav, Shital Vilas Wagh, Manjushri Pratap Dabhade
pp. 873-887 · DOI: 10.5530/ijpi.20250157 · 2025
Background: The need for new antibacterial medicines arises from the emergence of antibiotic-resistant bacterial strains. Pyranopyrazole derivatives, known for their diverse biological activities, are investigated for th…