International Journal of Pharmaceutical Investigation · Archive
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In this issue
21–40 of 43Original Article
Kinjal Shah, Hemani Joshi, Shailvi Shah, Tejal Mehta
pp. 569-578 · DOI: 10.5530/ijpi.20260096 · 2026
Background: This study aimed to develop and evaluate a taste-masked Medicated Chewing Gum (MCG) of Lornoxicam (LXM) using Kyron T-114, a weak cation exchange resin, to improve palatability and patient compliance. LXM, a …
Varsha Aniket Patole, Santosh Bhausaheb Dighe, Sapna Baban Khemnar, Gaurao subhash damare, Vaibhav vitthal bhone, Shweta Shantaram Jadhav
pp. 579-584 · DOI: 10.5530/ijpi.20260113 · 2026
Background: Olanzapine, a widely prescribed atypical antipsychotic, is associated with significant cardiometabolic side effects, including hypertension, dyslipidaemia, oxidative stress, inflammation, and QT interval prol…
Ahmed Mulfi Alharbi
pp. 585-589 · DOI: 10.5530/ijpi.20260049 · 2026
Aim/Background: Breast Cancer (BC) is one of the most common cancers affecting women globally. PIP5K1α catalyzes PtdIns-4,5-P2 (PIP2), a Precursor to PtdIns-3,4,5-P3 (PIP3), required for AKT activation. Overexpression of…
Shivalingayya Gadagayya Hiremath, Umesh Chaudhary, Giridhar Koratagere Sreekanth, Sai Keerthana Ravishankar, Manikanta Devaraj, Shailesh Yadav
pp. 590-598 · DOI: 10.5530/ijpi.20260331 · 2026
Background: Proton Pump Inhibitors (PPIs) are the most effective agents for managing acid related disorders. However, Inappropriate Prescribing of PPIs is becoming an issue of concern. Purpose: To review proton pump inhi…
Sanatkumar Bharamu Nyamagoud, Laxmi Bhimappa Totar, Hema Yadav, S M Shoaib Ahamed, Khandke Shruti Achyut, Vaishanavi Vanasakrithmath, R Ranjani, Tanushree R Bantanur, Chandan Ashok Naik, Shivani Mathapati, Spoorthi G Lakkannavar, K H Karthik
pp. 599-605 · DOI: 10.5530/ijpi.20260421 · 2026
Background: Rational drug use is essential to improving healthcare outcomes and minimizing risks such as antimicrobial resistance. This study evaluates prescription patterns in the General Medicine Department of an India…
Bhupinder Kumar, Raju Mudhulkar, Sreedhar Gundekari, Surbhi Tiwari, Dama Venugopala Rao, Lakki Reddy Prakash, Ramakrishna Yadav Belly, Sandeep Kumar
pp. 606-617 · DOI: 10.5530/ijpi.20260460 · 2026
Background: Packaging, storage and transportation of under varying climatic conditions have the quality concern in the drug products. This study followed the observed unknown impurity of ciprofloxacin eye drop. Materials…
Pranav Nayak, Mohammad Ali, DR Bharathi
pp. 618-624 · DOI: 10.5530/ijpi.20260468 · 2026
Background: Cognitive impairment signifies a reduction in mental abilities resulting from different factors like Alzheimer's disease leading to a diminished quality of life. Detecting it early and implementing interventi…
Akram Ahmed Aloqbi
pp. 625-637 · DOI: 10.5530/ijpi.20260075 · 2026
Background: Breast cancer, affecting roughly 2.3 million people each year, stands as a major global health concern due to its molecular complexity across subtypes such as luminal, HER2-enriched, and triple-negative. Thes…
Usha Dhoddametikurke Siddappa, Mandara Mathighatta Suresh, Mohd Sharique Katchhi, Babiker Bashir Haroun Baraka, Shilpashree Bettadapura Muralidhar, Chinthana Handankere Basavaraju, Chakure Aditya, Jyothi Murthy, Rajamma Abburu Jayaramu
pp. 638-644 · DOI: 10.5530/ijpi.20260558 · 2026
Background: Neurodegenerative and psychiatric disorders are often linked to oxidative stress and mitochondrial dysfunction, necessitating novel therapeutic strategies. Bacillus coagulans, a probiotic known for its role i…
Jayasutha Jayram, Jerad Suresh Ayyadurai, Jagadeesan Subramanian, Lokesh kumar Dhavanam Ramesh Babu, Mohanraj vadivelu, Naveen Raj Ravi Kumar, Silviya Jenifer John Bosco, Pravin Kumar Muthukumaresan, Sathya Samikkannu, Yashwan Babu, Raman Lakshmisundaram, Ramakrishnan Trichur Venkatakrishnan
pp. 645-653 · DOI: 10.5530/ijpi.20260608 · 2026
Background: Poisoning is a major public health issue in many countries, particularly in India, where exposures to pesticides, household agents, drugs, industrial chemicals, and animal toxins are common. Contributing fact…
Vinod Rajendra Tawate, Sanket Keshav Tambe, Shubham Popatrao Mankar, Nilima Mahesh Wani, Sneha Abhishek Vikhe, Manisha Dhondiram Sonawane, Rohit Jaysing Bhor
pp. 654-666 · DOI: 10.5530/ijpi.20260528 · 2026
Background: Using a variety of computational techniques, in silico studies allow for forecasting structural changes and how they would impact the pharmacological properties as well as the efficiency of these modification…
Rajesh Hadia, Kular Simran, Param Bhatt, Priyanka Yadav, Sarvajeet Khare, Cyril Sajan, Varunsingh Saggu, Hemraj Singh Rajput, Jitendra Lakhani
pp. 667-678 · DOI: 10.5530/ijpi.20260007 · 2026
Background: Sickle Cell Disease (SCD) is characterized by recurrent hospitalizations and painful Vaso-Occlusive Crises (VOCs). VOCs are prevalent and often necessitate hospital admissions. Aim and Objectives: This study …
Kamaladevi Kshatriya, Shivanand Swamy Panchayya Hiremath, Jathin Subhash Kalal, Fatima Sanjeri Dasankoppa, M Mahesh Yadav, Pradeep Bhimagouda Mirje, Jayatheertha Lokapur, Arpitha Lokapur, Rohan Ravsaheb Latwade, Pranav Babasaheb Patil
pp. 679-686 · DOI: 10.5530/ijpi.20260041 · 2026
Introduction: Emulgels are emerging as efficient topical drug delivery systems due to their dual-release mechanism, combining the benefits of both emulsions and gels. This system facilitates the enhanced delivery of hydr…
Papiya Bigoniya, Vanita Chature
pp. 687-701 · DOI: 10.5530/ijpi.20260554 · 2026
Background: Psoriasis is a persistent inflammatory skin condition marked by abnormal epidermal proliferation and excessive keratinization, impairing effective drug absorption. To overcome these barriers, topical formulat…
C Reddy Prasad, Bibi Umeza, M Yuvaraj, A K Afzal Khan, Swapna R Nayaka, Thirunavukkarasu Jayaraman
pp. 702-707 · DOI: 10.5530/ijpi.20260059 · 2026
Objectives: This study aims to evaluate the anti-glycemic and antioxidant qualities of Malus domestica fruit (apple), Musa acuminata Colla fruit (banana), Mangifera indica fruit (mango), Citrus reticulata fruit (orange),…
Mohammad Shane Alam, Yahia Mjery, Kamal Ahmad, Yahia Ali Kaabi, Mohammad Suhail Akhter, Fakhra Jabeen, Jobran Mohammad Moshi, Alaa Ali Alhazmi, Md Intekhabul Haque, Saif Elden Babikar Abdalla, Mathkour Hazem
pp. 708-714 · DOI: 10.5530/ijpi.20260150 · 2026
Background: Globally, Non-Alcoholic Fatty Liver Diseases (NAFLD) is considered as the frequent chronic liver diseases strongly linked with metabolic dysfunction and cardiovascular risk specifically in Type 2 Diabetes Mel…
Navpreet Singh Babbar, Rabinoor Singh, Arti Saini, Inderjeet Verma, Tarun Singh
pp. 715-721 · DOI: 10.5530/ijpi.20260403 · 2026
Background: Catheter-Associated Urinary Tract Infections (CAUTIs) pose a major concern in Intensive Care Units (ICUs) due to their association with prolonged catheterization and severe underlying conditions. These infect…
Rohith Kuppusamy, Keerthika Devaraj, Gayathri Thiruvengadam, Nandhakumar Kannan, Mohamed Ashik Ahamed Ibrahim, Sriniga Venkatesh, Raman Lakshmisundaram, Sindhu Selvam, Ruthresh Jaisankar, Aswin Venkadesh Ramamoorthy Renuga, Jayasutha Jayram, Satish Srinivas Kondaveeti
pp. 722-727 · DOI: 10.5530/ijpi.20260607 · 2026
Background: Radiation Dermatitis (RD) is the most common adverse effect of radiation therapy among the cancer patients, which has the potential to lower patients' quality of life. This study aimed to assess the health-re…
Supriya Waghmare, Shreeya Belwalkar, Amir Shaikh, Sidhhi Bansode, Akancha Kumari, Pooja Deshmane, Archana Nagare, Mohini Bhawane, Nitin Salunkhe
pp. 728-736 · DOI: 10.5530/ijpi.20260344 · 2026
Background: Euphorbia hirta, also known as the "asthma plant" or "snake weed," belongs to the Euphorbiaceae family. However, its oral use as a drug has certain limitations, such as low bioavailability and high first-pass…
Alhanouf Alhawiti, Mohamed TS Saleem, Ahmed Hasan Abdelazeem, Tahani Al Rahbeni
pp. 737-743 · DOI: 10.5530/ijpi.20260138 · 2026
Background: A retrospective study was conducted using Electronic Health Records (EHRs) from several hospitals in Saudi Arabia. Materials and Methods: All hypertensive patients who visited the hospitals between 2016 and 2…