International Journal of Pharmaceutical Investigation · Archive
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In this issue
21–40 of 50Original Article(continued)
Naresh Kumar Jothi, Senthil Kumar Dayalan, Deepa Sunder Rajan, Lakshmi Anil Madheshiya
pp. 1424-1433 · DOI: 10.5530/ijpi.20260052 · 2026
Background: In this study, with a mathematical model, we provide an epidemic model for Mpox virus infection. This paper aims to develop a mathematical epidemic model that captures some of the key characteristics of Mpox.…
Pratiksha Akki, M Mahesh Yadav, Fatima S Dasankoppa, Agadi Hiremath Viswanatha Swamy, M Pradeep Kumar, C. Manjula, Muneendra, Rohan Latwade, Shreya A. Prabhu, Reshma Vibhuti
pp. 1434-1444 · DOI: 10.5530/ijpi.20260139 · 2026
Background: Antimicrobial Resistance (AMR) presents a major global health concern, necessitating the development of novel antimicrobial agents and effective drug delivery systems. Lincomycin hydrochloride, a lincosamide …
Anbarasu Velan, Subramanian Somaskanthan
pp. 1445-1450 · DOI: 10.5530/ijpi.20260111 · 2026
Background: Hypertension is a major global health concern and a primary risk factor for cardiovascular morbidity and mortality. Azilsartan medoxomil, a novel angiotensin II receptor blocker, is effective in blood pressur…
Seema A. Gosavi, Pratiksha D. Bornare, Jyoti B. Tangde, Aditi S. Kulkarni
pp. 1451-1456 · DOI: 10.5530/ijpi.20260122 · 2026
Objectives: This research emphasizes validating the HPLC, HPTLC, and UV-visible techniques for the simultaneous quantitative measurement of Moxifloxacin (MOX) and Tolfenamic Acid (TA) in veterinary formulations. Material…
Robin George, Irshad Pasha, Bettur Jayappa Mahendra Kumar
pp. 1457-1463 · DOI: 10.5530/ijpi.20260206 · 2026
Background: Despite conventional cardiac agents, the prognosis of heart failure remains unmet to improve clinical presentations, and morbidity remains high. Growing evidence from multiple placebo-controlled studies on So…
Sagarla Usharani, Mohammed Mahboob Shareef, Ruhi Anjum, Vasavi Devireddy, Naseeb Basha Shaik, Palghat Krishnamani Lakshmi, Prasanthi Domaraju
pp. 1464-1473 · DOI: 10.5530/ijpi.20260207 · 2026
Background: The objective of this study is to create a nano emulsion-based gel, of efinaconazole, a class II (BCS) antifungal medication for onchomycosis, by increasing solubility. Materials and Methods: Solubility studi…
Susmita Mandal, Tejas Gadhave
pp. 1474-1478 · DOI: 10.5530/ijpi.20260135 · 2026
Objectives: Antimicrobial Resistance (AMR) is a growing public health crisis driven by the misuse and overuse of antibiotics. India, a major consumer of antibiotics, faces greater risks due to unregulated Over-the-Counte…
Israa Jameel Hakeem
pp. 1479-1488 · DOI: 10.5530/ijpi.20260027 · 2026
Background: Cyclin-Dependent Kinase is one of the important part the cell cycle control systems and normally active in breast cancer. DFT calculations, ADMET predictions and molecular docking on ligands such as compound …
Raj Deelip Mayanna, Siddhesh Santosh Bandekar, Shailendra Sanjay Suryawanshi, Mahesh Shivabasappa Palled, Priya Patil, Tanay Aniket Bhingurde, Sairaj Tukaram Bhogan, Ronak Dsouza, Yallurkar Siddhkala Suresh, Snehal Pundalik Yadav, Ashlesha Vilas Bhatakande, Soumya Ashok Biradar, Vrushali Vijay Patil, Arif Salim Jamadar
pp. 1489-1497 · DOI: 10.5530/ijpi.20260149 · 2026
Background: The present invention relates to an eco-sustainable, Quality by Design (QbD)- and Design of Experiments (DoE)-guided sonication-assisted extraction process for isolating cytotoxic flavonoid compounds from the…
Muvvala Divya, Shaheen Begum, Mounika Yammani, Basuthkar Vanitha Bai, Dudekula Usha Rani
pp. 1498-1505 · DOI: 10.5530/ijpi.20260155 · 2026
Background: Methocarbamol, a centrally acting skeletal muscle relaxant, exhibits poor aqueous solubility, limiting its bioavailability. Cocrystallization offers a promising approach to enhance solubility and dissolution …
K H Harish, Agadi Hiremath Viswanatha Swamy
pp. 1506-1518 · DOI: 10.5530/ijpi.20260196 · 2026
Objectives: This study focuses on the formulation and optimization of Solid Lipid Nanoparticles (SLNs) containing agmatine sulfate, with the goal of enhancing its bioavailability and minimizing rapid metabolic degradatio…
Niloufur Syed Bashutheen, Arivarasan Barathi, Logeswari Balaji Mani, Sowmya Anbazhagan, Rajan Rushender
pp. 1519-1526 · DOI: 10.5530/ijpi.20260204 · 2026
Introduction: Tuberculosis (TB) remains a major public health challenge, exacerbated by Adverse Drug Reactions (ADRs) associated with anti-TB treatment. ADRs can lead to treatment discontinuation, drug resistance, and po…
Nikhil Sunil Gawas, Meenaxi Maruti Maste
pp. 1527-1534 · DOI: 10.5530/ijpi.20260209 · 2026
Background: Major depressive disorders are treated with the antidepressant vortioxetine. In the current work, UV-Vis Spectroscopy was used to establish a new, simple, reliable, precise, selective, and ecologically sound …
Maryam Musleh Althobiti
pp. 1535-1540 · DOI: 10.5530/ijpi.20260013 · 2026
Background: Breast Cancer (BC) is a major global health concern, particularly among women, and the fatality rate is increasing. Cyclooxygenase-2 (COX-2) is a critical enzyme that is overexpressed in various human cancers…
Yogita Shinde, Gitanjali Deokar
pp. 1541-1549 · DOI: 10.5530/ijpi.20260222 · 2026
Objectives: Finger millet (Eleusine coracana) and flax seeds (Linum usitatissimum) are nutritious seeds and have multiple health benefits. But the nutrients, bioavailability, and functional quality of these foods may cha…
Nuziveeti Lakshmi Durga Bhavani, Lankadi Devi, Bolapati Gayathri Priya, Bikkina Aruna, Bommina Abhisri, G. Yuthika Lakshmi, Lakshmi Prasanthi Nori
pp. 1550-1556 · DOI: 10.5530/ijpi.20260258 · 2026
Objectives: The objective of the current study was to design and confirm a green, eco-friendly UV-visible spectrophotometric system of estimating Enalapril maleate using safe and cost-effective solvents. Materials and Me…
Rashed Mohammed Alghamdi
pp. 1557-1566 · DOI: 10.5530/ijpi.20260020 · 2026
Background: Lung cancer is a significant cause of cancer-related death, emphasizing the need for current targeted therapies. CDK4, an imperative regulator of cell-cycle progression and the G1/S transition, is a promising…
Tiyagura Nagaraja Kumari, Bachunaga Kishore Babu, Sree Pavani Vanteddu, K. Suryanarayana, Sripathi Kalvakolanu
pp. 1567-1577 · DOI: 10.5530/ijpi.20260260 · 2026
Objectives: This is a conceptual paper, which presents the Neurodiversity-Inclusive Leadership (NIL) as a unique model of leadership that incorporates cognitive diversity theory, psychological safety, strength-based stra…
Divya Ratnakumar Patil, Mahesh Palled, Shailendra Sanjay Suryawanshi, Priya Prakash Shetti, Vrushali Patil, Tanay Bhingurde, Simran Gawas, Ronak Dsouza, Sairaj Bhogan, Rakshita Hirakal, Siddhesh Bandekar, Vittal Gavali
pp. 1578-1592 · DOI: 10.5530/ijpi.20260266 · 2026
Background: NSAIDs, or Non-Steroidal Anti-Inflammatory medicines, are a large family of chemically diverse medications with a wide range of effects. Nepafenac is an anti-inflammatory medication that is used topically as …
Afaf Salim Alwabli
pp. 1593-1600 · DOI: 10.5530/ijpi.20260021 · 2026
Background: DENV NS5 is the most conserved viral protein; its N-terminal Methyltransferase (MTase) is essential for RNA capping and a prime drug target. The MTase domain mediates methylation of the viral RNA cap, ensurin…